中国临床药理学杂志2024，Vol.40Issue(5)：763-767,5.DOI:10.13699/j.cnki.1001-6821.2024.05.028
贝伐珠单抗相关性高血压的研究现状
Research status of bevacizumab associated hypertension
摘要
Abstract
Objective Bevacizumab has been clinically used in colorectal cancer,ovarian cancer,cervical cancer,non-small cell lung cancer and other tumor diseases.Common adverse reactions during bevacizumab treatment include albuminuria,thrombosis,bleeding,gastrointestinal perforation and hypertension,among which the incidence of hypertension is as high as 19％-47％.The occurrence of hypertension affects the quality of life of patients,hinds the normal development of tumor treatment,and even induces serious cardiovascular diseases and increases the risk of death,which requires clinical attention.In this paper,the mechanism,influencing factors,prognosis and related treatment of bevacizumab associated hypertension were reviewed,so as to provide reference for clinical rational drug use.关键词
贝伐珠单抗/血管生长因子/抗肿瘤血管生成/药物不良反应/高血压/ 预防和治疗Key words
bevacizumab/vascular growth factor/anti-tumor angiogenesis/adverse drug reaction/hypertension/prevention and treatment分类
医药卫生引用本文复制引用
王欢,马松涛,肖洪涛,陈燕,阴骏,徐珂,程凯..贝伐珠单抗相关性高血压的研究现状[J].中国临床药理学杂志,2024,40(5):763-767,5.基金项目
四川省个体化药物治疗重点实验室基金资助项目(2021YB03) （2021YB03）
中国药学会医院药学专业委员会科研专项基金资助项目(CPA-Z05-ZC-2022-002) （CPA-Z05-ZC-2022-002）
