中国临床药理学杂志2024，Vol.40Issue(5)：773-777,5.DOI:10.13699/j.cnki.1001-6821.2024.05.030
瑞马唑仑在围术期改善认知功能作用的研究现状
Research status of the role of remimazolam in improving cognitive function during perioperative period
摘要
Abstract
Postoperative cognitive dysfunction(POCD)is one of the common complications in the perioperative period,and it has a high incidence in elderly patients,and the large production of neuroinflammatory factors under surgical stimulation is the main cause of postoperative POCD.As an ultra-short-acting benzodiazepine of γ-aminobutyric acid receptor agonist,remimazolam can play a sedative-hypnotic and anxiolytic role in clinical practice,and can reduce inflammatory factors in the central nervous system and improve postoperative cognitive dysfunction by inhibiting neuroinflammatory response and oxidative stress.This article reviews the protective effect and mechanism of remimazolam on postoperative cognitive function,so as to provide a basis for the clinical use of remimazolam.关键词
瑞马唑仑/认知功能/炎症反应Key words
remimazolam/cognitive function/inflammation分类
医药卫生引用本文复制引用
蓝金辛,李森,杨铎,何俊冰,张隆盛..瑞马唑仑在围术期改善认知功能作用的研究现状[J].中国临床药理学杂志,2024,40(5):773-777,5.基金项目
广东省自然科学基金资助项目(2022A1515012413) （2022A1515012413）
广东省医学科学技术研究基金资助项目(B2022294) （B2022294）
广东省中医药局面上科研基金资助项目(20191409,20201463) （20191409,20201463）
