PITPNC1调控肿瘤细胞脂质代谢与铁死亡的研究进展OA北大核心CSTPCD

Lipid metabolism-mediated ferroptosis plays a crucial role in the initiation and progression of tumors,making it a focal point and challenge in current cancer research.The key regulatory molecules involved in controlling lipid metabolism and ferroptosis in tumors remain not fully understood.Studies have indicated that phosphatidylinositol transfer protein cytoplasmic 1(PITPNC1),a member of the phosphatidylinositol transfer protein family,specifically binds and transfers phosphatidylinositol and phosphatidic acid,facilitating the transfer of lipids across cell membranes and mediating lipid metabolism.Recently,it has been found that PITPNC1 is a lipid metabolism-related oncogene,highly expressed in various cancers such as breast,liver,gastric,colorectal,lung,and pancreatic cancers,and participates in regulating the growth,migration,and invasion processes of tumor cells.Here,the authors provide a review of the potential regulatory mechanisms of PITPNC1-mediated lipid metabolism-related signaling pathways on ferroptosis in tumor cells,so as to deepen our understanding of tumor cell ferroptosis and lipid metabolism,offers new perspectives for the development of targeted therapies in cancer treatment.