中国美容医学2024，Vol.33Issue(3)：1-5,5.
超分子水杨酸对兔耳痤疮模型p38MAPK/NF-κB信号通路的影响
Effect of Supramolecular Salicylic Acid on p38MAPK/NF-κB Signaling Pathway in Rabbit Ear Acne Models
摘要
Abstract
Objective To explore the effect of supramolecular salicylic acid on p38MAPK/NF-κB signaling pathway in rabbit ear acne model.Methods Divided thirty experimental rabbits into normal control group,2%SA group,30%SA group,fusidic acid group and model control group(There were 6 rabbits in each group)randomly.Gave corresponding external drug intervention for 4 weeks.Detected the expressions of p38MAPK,NF-κB,IL-1β and IL-8 after 2 weeks and 4 weeks.Results Result display,P38MAPK,NF-κB,IL-1β,and IL-8 of each group showed a downward trend after treatment.Before treatment,there were no significant differences in expression of p38MAPK,NF-κB,IL-1β and IL-8 among groups(P＞0.05).After 2 weeks of treatment,p38MAPK,NF-κB,IL-1β,and IL-8 of 2%SA group,30%SA group and fusidic acid group were lower than model control group(P＜0.001).There were no significant differences in p38MAPK,NF-κB,and IL-1β(P＞0.05).IL-8 of 2%SA group was lower than 30%SA group and fusidic acid group(all P＜0.05).There was no significant difference in IL-8 between 30%SA group and fusidic acid group(P＞0.05).After 4 weeks of treatment,p38MAPK,NF-κB,IL-1β,and IL-8 of three treatment groups were lower than model control group(P＜0.05).p38MAPK,NF-κB,IL-8 of 2%SA group and 30%SA group was lower than fusidic acid group(P＜0.05),IL-8 of 2%SA group was lower than 30%SA group(P＜0.05).There was no significant difference in p38MAPK between 2%SA group and 30%SA group(P＞0.05).2%SA group,30%SA group and fusidic acid group had no significant difference in IL-1β(all P＞0.05).2%SA group IL-1β was lower than 30%SA group,the difference was Statistical significance(P＜0.05).Conclusion Supramolecular salicylic acid can exert an anti-inflammatory effect by inhibiting the p38MAPK/NF-κB signaling pathway,and the curative effect gradually increases with the prolongation of medication time,and is superior to fusidic acid.关键词
痤疮/兔耳痤疮模型/超分子水杨酸/抗炎/p38MAPK/NF-κB信号通路Key words
acne/rabbit ear acne models/supramolecular salicylic acid/anti-inflammatory/p38MAPK/NF-κB signaling pathway分类
临床医学引用本文复制引用
杨力,刘尚可,林新瑜,罗霞,肖媛媛..超分子水杨酸对兔耳痤疮模型p38MAPK/NF-κB信号通路的影响[J].中国美容医学,2024,33(3):1-5,5.基金项目
四川省医学(青年创新)科研课题(编号:S19018) （青年创新）
四川省卫计委基金资助项目(编号:21PJ087) （编号:21PJ087）
