中国美容医学2024，Vol.33Issue(3)：6-11,6.
血清正五聚蛋白3对坏死性软组织感染的诊断效能研究
Study on the Diagnostic Efficacy of Serum Pentraxin 3 in Necrotic Soft Tissue Infection
摘要
Abstract
Objective To investigate the diagnostic efficacy of serum serum Pentraxin 3(PTX3)in necrotic soft tissue infection(NSTI).Methods 158 suspected NSTI patients who underwent emergency surgery in Kashgar First People's Hospital from June 2021 to June 2022 were selected as the study subjects,and they were divided into NSTI group(97 cases)and non NSTI group(61 cases)according to the results of postoperative diagnosis.Another 97 healthy people from the physical examination center of the hospital were selected as the health group.The levels of serum PTX3,C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate(ESR)and interleukin-6(IL-6)in NSTI group,non NSTI group at the time of admission and health group at the time of physical examination were compared,and the receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of the above indicators for NSTI.In addition,the changes of serum conventional inflammatory marks levels of patients in the NSTI group at the moment of admission,the second and third days of admission were observed,and the days of hospitalization,amputation rate and mortality rate of patients in the NSTI group were counted.In addition,the NSTI group was divided into necrotizing fasciitis group and gas gangrene group based on the postoperative diagnostic results,and the changes in serum conventional inflammatory marks levels between two groups at different times were compared,and the diagnostic efficacy of each indicator for necrotizing fasciitis and gas gangrene was observed.Results The levels of serum PTX3,CRP,PCT,ESR,IL-6 in NSTI group and non NSTI group were higher than those in healthy group(P＜0.05),which in the NSTI group were higher than those in non NSTI group(P＜0.05).ROC curve analysis showed that the sensitivity of serum PTX3 in diagnosing NSTI was higher than that of CRP,PCT,ESR and IL-6,and the specificity was slightly lower than PCT,but it was higher than CRP,ESR,IL-6,and area under the curve(AUC)was higher than CRP,PCT,ESR and IL-6.The serum PTX3,CRP,PCT,ESR,and IL-6 levels in the gas gangrene group were higher than those in the necrotizing fasciitis group(P＜0.05).The ROC curve analysis results showed that the sensitivity of serum PTX3 in diagnosing necrotizing fasciitis and gas gangrene was higher than that of CRP,PCT,ESR,and IL-6,and the specificity was the same as PCT,but higher than CRP,ESR,and IL-6,and the AUC was higher than CRP,PCT,ESR and IL-6.There were statistically significant differences in serum PTX3,CRP,PCT,ESR and IL-6 levels among groups,time and interaction effects immediately after admission,on the second day of admission and on the third day of admission(P＜0.05).The levels of serum indicators on the third day of admission were lower than those immediately and on the second day of admission(P＜0.05),and the gas gangrene group had higher levels of serum indicators on the first day,second day,and third day of admission than the necrotizing fasciitis group(P＜0.05).The average length of hospital stay,amputation rate and mortality rate in the gas gangrene group were higher than those in the necrotizing fasciitis group(P＜0.05).Conclusion The serum PTX3 level in NSTI patients are abnormally elevated,and patients with gas gangrene are all higher than those with necrotizing fasciitis.In addition,PTX3 is more effective in diagnosing NSTI and distinguishing necrotizing fasciitis from gas gangrene than conventional inflammatory indicators such as CRP,PCT,ESR,IL-6.关键词
正五聚蛋白3/坏死性软组织感染/坏死性筋膜炎/气性坏疽/死亡Key words
Pentraxin 3/necrotic soft tissue infection/necrotizing fasciitis/gas gangrene/mortality分类
医药卫生引用本文复制引用
李成志,乔维龙,鲁文,王静,阿布力米提·阿不都哈力克,孙向东..血清正五聚蛋白3对坏死性软组织感染的诊断效能研究[J].中国美容医学,2024,33(3):6-11,6.基金项目
新疆喀什地区科技局2021年科技计划项目(编号:KS2021079) （编号:KS2021079）
