中华耳科学杂志2023，Vol.21Issue(6)：871-875,5.DOI:10.3969/j.issn.1672-2922.2023.06.019
梅尼埃病患者内淋巴囊组织中细胞因子的表达
Expression of Cytokines in the Endolymphatic Sac in Patients with Meniere's Disease
黄梨 1汪芹 1黄超 1张智雯 1李葳 1刘伟 1彭安全 1周舟 1潘雪迎1
作者信息
- 1. 中南大学湘雅二医院耳鼻咽喉头颈外科,中南大学耳科研究所(长沙 410011)
- 折叠
摘要
Abstract
Objectiv Immune mediated inflammatory changes in the endolymphatic sac(ES)may underlie the mechanism of Meniere's disease(MD).The aim of the present study was to study the role of expression of proinflamma-tory cytokines in the ES in patients with MD as potential mechanisms underlying MD.Methods Human ES tissue was collected from patients with unilateral MD and patients with acoustic neuroma(AN)during surgery.Immunohistochemi-cal techniques were used to detect expression of tumor necrosis factor-α(TNF-α)and interferon-y(IFN-γ).Results Posi-tive immunostaining of TNF-α was identified in the ES epithelium,as well as in subepithelial connective-tissue fibro-blasts,in all 9 patients with MD,with strong epithelial cells staining in 5 patients,moderate levels of staining in 3 pa-tients and weak staining in 1 patient.IFN-y immunoreactivity was seen in the epithelial lining of the ES in 7 out of the 9 patients,with strong staining in 4 and moderate staining in 3 patients.In contrast,in 10 ES specimens from patients with AN,only weak TNF-α staining of epithelial cells was seen in 4 and negative in 6,with no expression of IFN-γ.Conclu-sions Positive expression of TNF-α and IFN-γ in the ES in patients with MD provides direct evidence of increased im-munologic activities in the ES microenvironment in patients with unilateral MD,suggesting that local inflammatory re-sponses may be a mechanism for this disease.关键词
梅尼埃病/内淋巴囊/肿瘤坏死因子α/干扰素γKey words
meniere's disease/endolymphatic sac/tumor necrosis factor-α/interferon-y分类
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黄梨,汪芹,黄超,张智雯,李葳,刘伟,彭安全,周舟,潘雪迎..梅尼埃病患者内淋巴囊组织中细胞因子的表达[J].中华耳科学杂志,2023,21(6):871-875,5.
