中华耳科学杂志2023，Vol.21Issue(6)：892-896,5.DOI:10.3969/j.issn.1672-2922.2023.06.023
钙黏蛋白CDH23与噪声性和老年性听力损失
Cadherin CDH23 and Noise-induced and Age-Related Hearing Loss
摘要
Abstract
Cadhearin 23(CDH23)is a component in the tip-links of inner ear hair cell stereocilia bundle.Muta-tions and variants in CDH23 have been found to cause a broad spectrum of hearing loss including syndromic hearing loss and congenital or progressive non-syndromic hearing loss.Based on our own research,we summarize the most im-portant discoveries in the past and update the recent research on the causal relationship between mutations and variants of CDH23 and noise-induced hearing loss(NIHL)as well as age-related hearing loss(ARHL)in this review.Current re-search data suggest that some mutations and variants of CDH23 cause increased susceptibility to NIHL and may contrib-ute to ARHL.We also discuss the current understanding of the molecular mechanism underlying CDH23 disease-causing mutations in hope of providing valuable information to researchers and students in this field.关键词
钙黏蛋白CDH23/噪声性听力损失/年龄相关性听力损失Key words
cadherin CDH23/noise-induced hearing loss(NIHL)/age-related hearing loss(ARHL)分类
医药卫生引用本文复制引用
王志炜,商嘉琪,奎丽红,梁燕霞,刘康宇,郑庆印,耿瑞双..钙黏蛋白CDH23与噪声性和老年性听力损失[J].中华耳科学杂志,2023,21(6):892-896,5.基金项目
Binzhou Medical University start-up fund,Innovation training plan program for college students(202110440084),Natural Sci-ence Foundation of Shandong Province Program(ZR2022MC149)大学生创新创业训练计划项目(202110440084) （202110440084）
山东省自然科学基金面上项目(ZR2022MC149)资助 （ZR2022MC149）
