Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthmaOA北大核心CSTPCDMEDLINE
Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma
Aging is a significant risk factor for various diseases,including asthma,and it often leads to poorer clinical outcomes,particularly in elderly individuals.It is recognized that age-related diseases are due to a time-dependent accumulation of cellular damage,resulting in a progressive decline in cellular and physiological functions and an increased susceptibility to chronic diseases.The effects of aging affect not only the elderly but also those of younger ages,posing significant challenges to global healthcare.Thus,understanding the molecular mechanisms associated with aging in different diseases is essential.One intriguing factor is the aryl hydrocarbon receptor(AhR),which serves as a cytoplasmic receptor and ligand-activated transcription factor and has been linked to the aging process.Here,we review the literature on several major hallmarks of aging,including mitochondrial dysfunction,cellular senescence,autophagy,mitophagy,epigenetic alterations,and microbiome disturbances.Moreover,we provide an over-view of the impact of AhR on these hallmarks by mediating responses to environmental exposures,particularly in relation to the immune system.Furthermore,we explore how aging hallmarks affect clinical characteristics,inflammatory features,exacerba-tions,and the treatment of asthma.It is suggested that AhR signaling may potentially play a role in regulating asthma phenotypes in elderly populations as part of the aging process.
Tianrui Yang;Rongjun Wan;Wei Tu;Sai Nithin Awaru;Peisong Gao
Division of Allergy and Clinical Immunology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21224,USA||Department of Geriatric Medicine,The First People's Hospital of Yunnan Province,Kunming,Yunnan 650032,ChinaDivision of Allergy and Clinical Immunology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21224,USA||Department of Respiratory Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,ChinaDivision of Allergy and Clinical Immunology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21224,USA||The State Key Laboratory of Respiratory Disease for Allergy,Shenzhen Key Laboratory of Allergy and Immunology,Shenzhen University School of Medicine,Shenzhen,Guangdong 518055,ChinaDivision of Allergy and Clinical Immunology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore,MD 21224,USA
AgingEnvironmentReactive oxygen speciesSenescenceAryl hydrocarbon receptorAsthma
《中华医学杂志（英文版）》 2024 (004)
382-393 / 12
This work was supported by grants from the US National Institutes of Health(NIH)(Nos.1R01AI153331 and R01AI141642),and the Department of Science and Technology of Yunnan Province,China(No.202201AY070001-260).
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