Chronic stress as an emerging risk factor for the development and progression of gliomaOA北大核心CSTPCDMEDLINE
Chronic stress as an emerging risk factor for the development and progression of glioma
Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system.Com-pared with patients with other cancers,glioma patients often suffer from increased levels of psychological stress,such as anxiety and fear.Chronic stress(CS)is thought to impact glioma profoundly.However,because of the complex mechanisms underlying CS and variability in individual tolerance,the role of CS in glioma remains unclear.This review suggests a new proposal to redivide the stress system into two parts.Neuronal activity is dominant upstream.Stress-signaling molecules produced by the neuroendocrine system are dominant downstream.We discuss the underlying molecular mechanisms by which CS impacts glioma.Potential pharmacological treatments are also summarized from the therapeutic perspective of CS.
Lan Yi;Xiang Lin;Xiaoling She;Wei Gao;Minghua Wu
Institute of Cytology and Genetics,The Hengyang Key Laboratory of Cellular Stress Biology,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,ChinaInstitute of Cytology and Genetics,The Hengyang Key Laboratory of Cellular Stress Biology,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China||Department of Pathology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China||Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Changsha,Hunan 410008,ChinaDepartment of Pathology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,ChinaKey Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Changsha,Hunan 410008,China||NHC Key Laboratory of Carcinogenesis,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China
Chronic stressGliomaMicrobiota-gut-brain axisNeuroendocrine systemStress systemNeural circuit
《中华医学杂志（英文版）》 2024 (004)
394-407 / 14
This work was supported by the Hunan Natural Science Foundation(Nos.2022JJ30478 and 2019JJ50509),the Key Scientific Research Project of Hunan Health Com-mission(No.202102051816),the project of Hengyang Science and Technology Bureau(No.2020jh042),and the Graduate Scientific Research and Innovation Project of Central South University(No.2022ZZTS0875).
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