中国畜牧杂志2024，Vol.60Issue(3)：79-87,9.DOI:10.19556/j.0258-7033.20230331-04
脂滴功能及其与卵母细胞成熟和胚胎发育的关系研究进展
Research Progress on Lipid Droplet Function and Its Relationship with Oocyte Maturation and Embryonic Development
摘要
Abstract
Lipid droplets are not only important organelles that store neutral lipids,such as triglycerides and cholesterol esters in eukaryotic cells,but central regulators of cell metabolism and organelle quality control.They participate in the regulation of cell energy metabolism,steroid hormone synthesis,endoplasmic reticulum stress,mitochondrial function and cellular membrane structure formation.It has been demonstrated that lipid droplets are synthesized at the endoplasmic reticulum and their budding occurs towards the cytoplasm.Lipid droplets are dynamic distributed organelles,and their number,size and distribution are influenced by cellular nutrient availability and metabolic status.It is well known that mammalian oocytes contain lipid droplets,and the sufficient amount of lipid droplets in animal oocytes has been closely related to oocyte maturation and early embryonic development.More importantly,recent studies have revealed that lipid droplets play a crucial role during embryo implantation,and the maintenance of an appropriate amount of lipid droplets in oocytes with low lipid droplet content is important for early embryonic development.Therefore,this paper summarizes the synthesis and distribution of lipid droplets,analyzes the main functions of lipid droplets,focuses on the key role of lipid droplets during animal oocytes and early embryonic development,and discusses the relationship between lipid droplets content in oocytes and embryos and the duration of embryonic diapause,which will provide reference for enhancing oocyte quality and embryonic development ability by regulating lipid droplets metabolism,thereby improve animal fertility in the future.关键词
脂滴/功能/卵母细胞成熟/胚胎发育Key words
Lipid droplet/Function/Oocyte maturation/Embryonic Development分类
畜牧业引用本文复制引用
高志刚,杜立银,关洪玉,贾振伟..脂滴功能及其与卵母细胞成熟和胚胎发育的关系研究进展[J].中国畜牧杂志,2024,60(3):79-87,9.基金项目
内蒙古自治区重点研发和成果转化计划(科技支撑东北振兴)项目(2022YFDZ0075) （科技支撑东北振兴）
内蒙古自治区自然科学基金项目(2022LHMS03018) （2022LHMS03018）
内蒙古自治区直属高校基本科研业务费项目(GXKY22002) （GXKY22002）
