某院139例儿童应用泊沙康唑情况分析OACSTPCD

Objective:To review the application of posaconazole in children in our hospital,so as to provide reference for rational drug use in clinic.Methods:Medication,outcome,drug combination and adverse drug reactions of 139 children administrated with posaconazole in our hospital from May 2021 to Apr.2022 were retrospectively analyzed.Results:Posaconazole was used in prophylaxis against invasive fungal disease(IFD)and treatment of Candidiasis,Aspergillosis and Mucormycosis.The selection of drugs and dosage forms was rational and the dose was appropriate.The proportion of deaths and abandoning treatment was significantly higher in children with poor response or infection progression than in those without infection progression.There were many varieties of drug combination.Allergic reaction and phlebitis respectively occurred in 1 case and liver adverse drug reaction was observed in 2 cases.Conclusion:The application of posaconazole is rational and safe in our hospital.However,drug combination should be further regulated.It is necessary to perform therapeutic drug monitoring(TDM)and adjust the dosing regimen in time to ensure the safety and effectiveness of medication in children.