儿科药学杂志2024，Vol.30Issue(3)：39-42,4.DOI:10.13407/j.cnki.jpp.1672-108X.2024.03.010
1例苯唑西林致儿童药物性肝损伤病例分析并文献复习
Case Analysis and Literature Review of a Case of Drug-Induced Liver Injury by Oxacillin in a Child
摘要
Abstract
Objective:To provide reference for drug-induced liver injury(DILI)by oxacillin.Methods:A case of a 6-month-old girl with DILI due to postoperative application of oxacillin injection for congenital heart disease in a hospital was analyzed,and relevant domestic and international literature was reviewed.Results:A total of 9 cases of related domestic and foreign literature were retrieved.Combined with the analysis of this case,it was found that 10 cases of children with different degrees of liver function injury after treatment with oxacillin,and liver function recovered after drug withdrawal.The liver function injury of children might be related to direct liver injury induced by oxacillin.Conclusion:Intravenous oxacillin in children should be administered at the dose recommended in the drug instructions or guidelines and with attention to changes in liver function,with prompt drug withdrawal,evaluation,and symptomatic management if necessary in the event of DILI.关键词
苯唑西林/药物性肝损伤/儿童/肝功能Key words
oxacillin/drug-induced liver injury/children/liver function分类
医药卫生引用本文复制引用
曹小雨,葛洁,王婧雯,王莹..1例苯唑西林致儿童药物性肝损伤病例分析并文献复习[J].儿科药学杂志,2024,30(3):39-42,4.基金项目
国家自然科学基金资助项目,编号72074218. （）
