儿科药学杂志2024，Vol.30Issue(3)：43-46,4.DOI:10.13407/j.cnki.jpp.1672-108X.2024.03.011
倍他米松联合硫酸镁治疗未足月胎膜早破的疗效观察
Efficacy of Betamethasone Combined with Magnesium Sulfate on Preterm Premature Rupture of Membranes
摘要
Abstract
Objective:To explore the effective treatment of preterm premature rupture of membranes.Methods:A total of 120 preterm pregnant women with premature rupture of membranes with gestational weeks from 28 to 34(33.47±3.19)weeks admitted into our hospital were extracted to be divided into the control group and study group according to different treatment regimens,with 60 cases in each group.The control group was treated with betamethasone(12 mg intramuscular injection),while the study group received betamethasone combined with magnesium sulfate,all indicators were evaluated after 2 d.Levels of inflammatory factors(IL-2 and TNF-α),continuous treatment duration,prolonged gestational weeks,uterine contraction inhibition time,postpartum hemorrhage,anxiety,delivery outcome such as Apgar score,birth weight of neonates,incidence of puerperal infection and incidence of neonatal respiratory distress syndrome(NRDS),neonatal lung function,incidence of adverse drug reactions were compared between two groups.Results:After treatment,serum levels of IL-2 and TNF-α in both groups decreased,and the study group was lower than the control group(P＜0.01).The treatment duration and uterine contraction inhibition time in the study group were shorter than those in the control group,and the prolonged gestational weeks was longer than those in the control group(P＜0.05).The Apgar score and birth weight of neonates in the study group were higher than those in the control group,and the incidences of NRDS and neonatal asphyxia in the study group were lower than those in the control group(P＜0.05).On the 1st and 7th day of birth,the airway resistance in the study group was significantly lower than that in the control group,the functional residual capacityand and lung compliance were significantly higher than those in the control group(P＜0.01).Conclusion:Betamethasone combined with magnesium sulfate in the treatment of patients with preterm premature rupture of membranes can effectively reduce inflammation and incidence of NRDS,shorten treatment duration,improve delivery outcomes and lung function without increasing the incidence of adverse drug reactions.关键词
未足月胎膜早破/倍他米松/硫酸镁/分娩结局/Apgar评分Key words
preterm premature rupture of membranes/betamethasone/magnesium sulfate/delivery outcome/Apgar score分类
医药卫生引用本文复制引用
邹昌军,师蕊,蔡树梅,王亚敏,张金玲,李燕..倍他米松联合硫酸镁治疗未足月胎膜早破的疗效观察[J].儿科药学杂志,2024,30(3):43-46,4.基金项目
河北省医学科学研究课题计划项目,编号20191810. （）
