儿科药学杂志2024，Vol.30Issue(3)：46-50,5.DOI:10.13407/j.cnki.jpp.1672-108X.2024.03.012
左沙丁胺醇在联合雾化吸入中的稳定性研究
Stability Analysis of Levosalbutamol during Atomization Inhalation
刘倩 1王琛 1孙楠 1白应德 1任艳丽1
作者信息
- 1. 郑州大学第三附属医院,郑州 450052
- 折叠
摘要
Abstract
Objective:To develop the high performance liquid chromatography method for the chiral separating enantiomers of salbutamol,and to explore the stability of levosalbutamol(R-salbutamol)during atomization inhalation.Method:Salbutamol enantiomers were separated by Chiralpak IC(250 mm×4.6 mm,5 μm)at 25℃and the mobile phase used was hexane-isopropanol(80∶20,V/V,0.1％diethylamine)at a flow rate of 0.8 mL/min,the detection wavelength was 226 nm.Budesonide and R-salbutamol were atomized for 30 min,then the sample solution was prepared to explore the stability of R-salbutamol.Results:Salbutamol enantiomers was separated completely and the resolution was 2.12.The first effluent was R-salbutamol.Compared with the chromatograms of R-salbutamol inhalation solution after combined atomization and just unwrapped,the peak type and peak area did not change much,indicating that R-salbutamol was stable in combined atomization.Conclusion:The method allows easy separation of the enantiomers of salbutamol and good stability of R-salbutamol when nebulized for 30 min in combination with budesonide.关键词
手性拆分/高效液相色谱法/雾化吸入/R-沙丁胺醇Key words
chiral separation/high performance liquid chromatography/atomization inhalation/R-salbutamol分类
医药卫生引用本文复制引用
刘倩,王琛,孙楠,白应德,任艳丽..左沙丁胺醇在联合雾化吸入中的稳定性研究[J].儿科药学杂志,2024,30(3):46-50,5.
