医学分子生物学杂志2024，Vol.21Issue(2)：124-128,5.DOI:10.3870/j.issn.1672-8009.2024.02.005
血清Asprosin水平与老年2型糖尿病肾病的相关性分析
Correlation Analysis of Serum Asprosin Levels and Elderly Patients with Type 2 Diabetic Nephropathy
摘要
Abstract
Objective To analyze the correlation between serum Asprosin levels and elderly type 2 diabetic nephropathy(DN)to provide clues for the search of new early indicators of DN in clinical practice.Methods A total of 183 patients with type 2 diabetes mellitus(T2DM)admitted to our hospital from August 2021 to March 2022 were included for this study.According to whether the patients have DN or not,the patients were divided into 2 groups:the T2DM group alone(85 cases)and the combined DN group(98 cases).Another 50 healthy patients were selected for the control group.The serum Asposin levels in each group was detected and the diagnostic efficacy of As-posin in early DN was analyzed.Results Asprosin levels were significantly higher in the T2DM group[(1.64±0.41)ng/mL]and the combined DN group[(2.45±0.52)ng/mL]when compared with that in the control group[(1.15±0.23 ng/mL],and Asprosin level in the com-bined DN group was higher than that in the T2DM group(P<0.05).Asprosin level was positively correlated with the values of BUN,Cr,UA,HbA1c,FINS,HOMA-IR,UAER(P<0.05).The level of Asprosin,HbA1c and UAR were risk factors affecting the occurrence of DN(P<0.05).The area under the curve for the diagnosis of DN by Asprosin combined with UAER was 0.879(95%CI:0.813-0.974,P<0.05),the diagnostic specificity was 84.19%,and the sensitivity was 94.57%.Conclusion Elderly DN patients exhibit higher expression of serum As-prosin levels,which may serve as an early diagnostic indicator for the presence of diabetic nephrop-athy in elderly type 2 diabetes patients.关键词
2型糖尿病/白脂素/糖尿病肾病/标志物Key words
type 2 diabetes/Asprosin/diabetic nephropathy/biomarker分类
医药卫生引用本文复制引用
刘田,范静静,陈梦楠,郭梦圆,卢海龙..血清Asprosin水平与老年2型糖尿病肾病的相关性分析[J].医学分子生物学杂志,2024,21(2):124-128,5.基金项目
2021年度江苏省老年健康科研项目(No.LD2021023),徐州市科技项目(No.KC16SH078) This work was supported by grants from the 2021 Jiangsu Province Elderly Health Research Project(No.LD2021023),Xuzhou City Science and Tech-nology Project(No.KC16SH078) （No.LD2021023）
