let-7i-5p在肿瘤中的研究进展OACSTPCD
Research Progress on Role of let-7i-5p in Tumor
let-7i-5p是非编码小分子RNA(miRNA)中的一员,它通过多靶点和信号通路来抑制肿瘤的生长、增殖和迁移,还具有调节肿瘤微环境延缓癌症进展和改善肿瘤耐药的作用.文章综述了let-7i-5p在肝癌、乳腺癌、结直肠癌、宫颈癌、鼻咽癌、肾癌和胶质母细胞瘤中的研究进展.有望发掘let-7i-5p成为新肿瘤标志物,为肿瘤的防治提供新策略.
let-7i-5p is a member of non-coding small molecule RNA(miRNA),which inhib-its tumor growth,proliferation and migration through multiple targets and signaling pathways.It also has the effect of regulating tumor microenvironment to delay cancer progression and improve tumor drug resistance.This article reviews the research progress of the mechanism of let-7i-5p in liver cancer,breast cancer,colon cancer,cervical cancer,nasopharyngeal cancer,kidney cancer and glioblastoma.It is expected to explore the role that let-7i-5p can play as a new tumor marker to pro-vide a new strategy for tumor prevention and treatment.
偶勇;董佳琪;王斑;李媛媛;王树楷;晁旭
陕西中医药大学 陕西省咸阳市,712000陕西中医药大学第二附属医院 陕西省咸阳市,712000
生物学
let-7i-5p肿瘤机制研究
let-7i-5ptumormechanism
《医学分子生物学杂志》 2024 (002)
土贝母通过炎性小体调控caspase-1诱导肝癌细胞焦亡抑制肝癌发生发展的机制研究
166-170 / 5
国家自然科学基金(No.81774132),陕西省中医药"双链融合"中青年科研创新团队建设项目(No.2022-SLRH-LJ-010),陕西省中医药管理局科研项目(No.2021-zz-JC001) This work was supported by grants from the National Natural Science Foundation of China(No.81774132),Shaanxi Province Traditional Chinese Medicine"Double Chain Integration"Research and Innovation Team Building Project(No.2022-SLRH-LJ-010),Shaanxi Province Traditional Chinese Medicine Administration Research Project(No.2021-zz-JC001)
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