幽门螺杆菌毒力因子CagA的基因表达调控机制研究进展OACSTPCD
Advances in Gene Expression Regulatory Mechanism of Helicobacter pylori Virluence Factor CagA
全球约有一半人口感染了幽门螺杆菌(Helicobacter pylori,H.pylori),特别是发展中国家的感染率极高.目前,幽门螺杆菌感染已被列为胃癌发生的高危因素.幽门螺杆菌感染的致病机制被认为与环境因素、宿主易感性和细菌毒力等因素之间复杂的相互作用有关.文章主要对幽门螺杆菌毒力因子细胞毒素相关基因(cytotoxin-associated gene A,cagA)表达调控的分子机制进行综述,以便更好地理解cagA的致病性,为今后预防和治疗由幽门螺杆菌所引起的疾病提供理论参考.
About half of the global population has been found to be infected with Helicobacter pylori(H.pylori),with particularly high rates in developing countries.Currently,H.pylori infec-tion has been listed as a high-risk factor for the development of gastric cancer.The pathogenesis of H.pylori infection is believed to be associated with complex interactions between environment fac-tors,host susceptibilities,and bacterial pathogenicity.Therefore,this article reviews the molecular mechanism of the regulation of Helicobacter pylori independent factor cagA expression,in order to better understand the pathogenicity of cagA and to provide a theoretical reference for the future pre-vention and treatment of diseases caused by H.pylori.
王萌萌;余梦超;王莉莉;赵振宇;董全江
青岛市市立医院中心实验室 山东省青岛市,266000||山东第二医科大学临床医学院 山东省潍坊市,261000青岛市市立医院中心实验室 山东省青岛市,266000青岛市市立医院中心实验室 山东省青岛市,266000||大连医科大学研究生院 辽宁省大连市,116000
基础医学
幽门螺杆菌cagA调控机制
Helicobacter pyloricytotoxin-associated gene Aregulatory mechanism
《医学分子生物学杂志》 2024 (002)
171-175 / 5
国家自然科学基金(No.31870777) This work was supported by a grand from the National Natural Science Foundation of China(No.31870777)
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