糖皮质激素诱导小梁网组织失能的研究进展OACSTPCD
Research Progress on Glucocorticoids Induced Dysfunction of Trabec-ular Meshwork
糖皮质激素(glucocorticoids,GCs)作用于小梁网组织,诱导发生组织形态学的改变与功能失衡.研究证实糖皮质激素性青光眼与原发性开角型青光眼(primary open angle glaucoma,POAG)具有相似的小梁网形态与功能变化,然而POAG的发病机制仍不清楚.阐明GCs如何诱导小梁网形态学的改变,如何影响房水流出阻力,有利于探索POAG的发病机制.文章主要就GCs对小梁网的影响作一综述.
Glucocorticoids(GCs)could induce the morphological changes and dysfunction of trabecular meshwork tissues.The changes in the trabecular meshwork tissues of the glucocorticoids(GCs)induced glaucoma is similar with those of the primary open angle glaucoma(POAG).However,the pathogenesis of POAG is still unclear,elucidating how GCs induce morphological changes of trabecular meshwork and the increase of aqueous humor outflow resistance is beneficial for exploring the pathogenesis of POAG.The effects of GCs on trabecular meshwork are summarized in this review.
任静;段世超;崔慧玲;王迪;赵茹梦;李海军
河南省人民医院,河南省立眼科医院,郑州大学人民医院,河南大学人民医院 郑州市,450003
临床医学
糖皮质激素小梁网激素性高眼压青光眼
glucocorticoidstrabecular meshworkglucocorticoid induced ocular hyperten-sionglaucoma
《医学分子生物学杂志》 2024 (002)
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国家自然科学基金(No.U1904166) This work was supported by a grant from the National Natural Science Foundation of China(No.U1904166)
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