医学分子生物学杂志2024，Vol.21Issue(2)：182-186,5.DOI:10.3870/j.issn.1672-8009.2024.02.015
缺氧在肺癌的进展与治疗耐受产生中的作用机制研究进展
Advances in Mechanism of Hypoxia in the Progression and Treatment Tolerance of Lung Cancer
陈科名 1俞万钧 1王华英 1傅中明1
作者信息
- 1. 宁波大学附属人民医院呼吸与危重症医学科 浙江省宁波市,315040
- 折叠
摘要
Abstract
Hypoxia is an intrinsic feature of lung cancer.It affects the metabolism,proliferation and migration of lung cancer through genomic and proteomic regulation,and up-regulates the toler-ance of lung cancer to radiotherapy and induces the resistance of lung cancer to chemotherapy and immunotherapy through complex mechanisms,which make it an important factor leading to the poor prognosis of lung cancer.This article reviews the mechanism of hypoxia in the drug resistance of lung cancer and its potential application as a therapeutic target in the clinical treatment of lung cancer.关键词
缺氧/肺癌/耐药性Key words
hypoxia/lung cancer/drug resistance分类
医药卫生引用本文复制引用
陈科名,俞万钧,王华英,傅中明..缺氧在肺癌的进展与治疗耐受产生中的作用机制研究进展[J].医学分子生物学杂志,2024,21(2):182-186,5.
