缺氧在肺癌的进展与治疗耐受产生中的作用机制研究进展OACSTPCD
Advances in Mechanism of Hypoxia in the Progression and Treatment Tolerance of Lung Cancer
缺氧是肺癌的内在特征,其通过对基因组学和蛋白组学表达的调控来影响肺癌的代谢、增殖和迁移,并通过复杂的机制上调肺癌对放疗的耐受性、诱导肺癌对化疗、免疫治疗的耐药性,是导致肺癌预后不良的重要因素.文章就缺氧在肺癌进展中的作用及治疗过程中影响耐药性的作用机制及其作为治疗靶点在肺癌临床治疗中的应用可能作一综述.
Hypoxia is an intrinsic feature of lung cancer.It affects the metabolism,proliferation and migration of lung cancer through genomic and proteomic regulation,and up-regulates the toler-ance of lung cancer to radiotherapy and induces the resistance of lung cancer to chemotherapy and immunotherapy through complex mechanisms,which make it an important factor leading to the poor prognosis of lung cancer.This article reviews the mechanism of hypoxia in the drug resistance of lung cancer and its potential application as a therapeutic target in the clinical treatment of lung cancer.
陈科名;俞万钧;王华英;傅中明
宁波大学附属人民医院呼吸与危重症医学科 浙江省宁波市,315040
临床医学
缺氧肺癌耐药性
hypoxialung cancerdrug resistance
《医学分子生物学杂志》 2024 (002)
182-186 / 5
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