临床肝胆病杂志2024，Vol.40Issue(3)：573-580,8.DOI:10.12449/JCH240322
双向孟德尔随机化分析总胆固醇升高风险与胆石症发生风险的关系
Association between the risk of increase in total cholesterol and the risk of cholelithiasis:A bidirectional Mendelian randomization study
赵伟伟 1杜晓旭 2戈宏焱3
作者信息
- 1. 内蒙古民族大学临床医学院,内蒙古 通辽 028000||兴平市汤坊镇卫生院,陕西 兴平 713100
- 2. 内蒙古民族大学临床医学院,内蒙古 通辽 028000
- 3. 内蒙古民族大学医学院,内蒙古 通辽 028000
- 折叠
摘要
Abstract
Objective To investigate the association between the risk of increase in total cholesterol(TC)and the risk of cholelithiasis by using bidirectional Mendelian randomization(MR).Methods The open gwas public database was used to obtain the single nucleotide polymorphism data associated with TC and cholelithiasis,and a secondary data analysis was performed for all summary data of genome-wide association studies.The genetic loci closely associated with TC or cholelithiasis were selected as exposure or outcome variables,and the bidirectional MR analysis was performed using the methods such as Egger regression,Weighted median,IVW random effects model,and IVW fixed effects model,with odds ratio(OR)values for evaluating the causal relationship between TC and cholelithiasis.Results With TC as the exposure and cholelithiasis as the outcome,TC-cholelithiasis had an overall OR value of 0.91(95%confidence interval[CI]:0.85—0.97)before elimination of heterogeneity and 0.93(95%CI:0.89—0.97)after elimination of heterogeneity.With cholelithiasis as the exposure and TC as the outcome,TC-cholelithiasis had an overall OR value of 0.20(95%CI:0.06—0.65)before elimination of heterogeneity and 0.28(95%CI:0.10—0.83)after elimination of heterogeneity.There was a bidirectional causal relationship between genetically predicted TC and cholelithiasis.Conclusion This study confirms the bidirectional causal relationship between TC and cholelithiasis.The risk of cholelithiasis decreases with the increase in alleles associated with the elevation of TC level;on the contrary,the risk of elevated TC level decreases with the increase in alleles associated with the onset of cholelithiasis.关键词
总胆固醇/胆石症/双向孟德尔随机化分析Key words
Total Cholesterol/Cholelithiasis/Bidirectional Mendelian Randomization Analysis引用本文复制引用
赵伟伟,杜晓旭,戈宏焱..双向孟德尔随机化分析总胆固醇升高风险与胆石症发生风险的关系[J].临床肝胆病杂志,2024,40(3):573-580,8.
