临床肝胆病杂志2024，Vol.40Issue(3)：589-593,5.DOI:10.12449/JCH240325
孟德尔随机化分析方法在非酒精性脂肪性肝病病因探索中的应用
Application of Mendelian randomization analysis in exploring the etiology of nonalcoholic fatty liver disease
摘要
Abstract
Nonalcoholic fatty liver disease(NAFLD)is an abnormal lipid metabolic disorder of the liver characterized by accumulation of a large amount of lipids in the liver,and it is currently the most common liver disease around the world.Mendelian randomization(MR)incorporates genomic data into traditional epidemiological study designs to infer the causal relationship between exposure factors and disease risk.In recent years,MR has been widely used in studies on inference of the etiology of NAFLD.This article systematically summarizes the advances in the application of MR in NAFLD research,so as to provide new ideas for understanding the nature of the disease and scientific interventions.关键词
非酒精性脂肪性肝病/孟德尔随机化分析/因果律/工具变量Key words
Non-alcoholic Fatty Liver Disease/Mendelian Randomization Analysis/Causality/Instrumental Variables引用本文复制引用
郭紫薇,武庆娟,叶永安,陈兰羽,吕文良..孟德尔随机化分析方法在非酒精性脂肪性肝病病因探索中的应用[J].临床肝胆病杂志,2024,40(3):589-593,5.基金项目
中国中医科学院科技创新工程(CI2021A00801,CI2021A00802) Science and Technology Innovation Project of the Chinese Academy of Traditional Chinese Medicine(CI2021A00801,CI2021A00802) （CI2021A00801,CI2021A00802）
