临床肝胆病杂志2024，Vol.40Issue(3)：616-620,5.DOI:10.12449/JCH240330
肝硬化凝血障碍机制的再认识
Re-understanding of the mechanism of coagulation disorder in liver cirrhosis
摘要
Abstract
The liver plays an important regulatory role in maintaining the dynamic balance of coagulation and anticoagulation in the body.Such dynamic balance is fragile in patients with liver cirrhosis,and the risk of bleeding can be increased due to reductions in coagulation factors and platelet count and excessive fibrinolysis;meanwhile,thrombus can be formed due to the increases in von Willebrand factor and coagulation factor Ⅷ,the reductions in anticoagulant protein C and anticoagulant protein S,the increase in thrombin-generating potential,and alterations in antifibrinolytic components.This article reviews the mechanisms of coagulation disorder in liver cirrhosis,so as to help clinicians with the prevention and treatment of bleeding or thrombotic disorders in patients with liver cirrhosis.关键词
肝硬化/血液凝固/出血/血栓形成Key words
Liver Cirrhosis/Blood Coagulation/Haemorrhage/Thrombosis引用本文复制引用
孙荣荣,贺娜,张粉娜,张心怡,王梓依,王辉,边娜娜,闫红林..肝硬化凝血障碍机制的再认识[J].临床肝胆病杂志,2024,40(3):616-620,5.基金项目
陕西省教育科学"十三五"规划课题(SGH20Y1330) （SGH20Y1330）
佑安肝病传染病专科医疗联盟专项基金(LM202003) （LM202003）
陕西基础科学(化学、生物学)研究院2022年度基础科学研究计划项目(22JHQ091) Shaanxi Provincial Education Science"13th Five-Year Plan"Project(SGH20Y1330) （化学、生物学）
Youan Specialist Medical Alliance for Liver and Infectious Diseases Special Fund(LM202003) （LM202003）
Shaanxi Institute of Basic Science(Chemistry and Biology)2022 Basic Science Research Programme Projects(22JHQ091) （Chemistry and Biology）
