临床肝胆病杂志2024，Vol.40Issue(3)：626-632,7.DOI:10.12449/JCH240332
何首乌致肝损伤的信号通路及其作用机制
Mechanism of action of Polygonum multiflorum in inducing liver injury:A study based on signaling pathways
摘要
Abstract
Polygonum multiflorum(PM),a commonly used Chinese herbal medicine in clinical practice,has been associated with frequent reports of liver injury in recent years,and the medication safety of PM has attracted more and more attention in China and globally.This article reviews the recent research advances in the signaling pathways and mechanisms of PM in causing drug-induced liver injury(DILI)and aims to provide new ideas for the proper and rational use of PM in clinical practice.The results show that PM is involved in the regulation of various signaling pathways,and it leads to the death of hepatocytes by destroying mitochondrial function,exacerbating bile acid accumulation,and inducing immune response,oxidative stress,and endoplasmic reticulum stress,thereby inducing the development and progression of DILI through multiple targets,pathways,and levels.关键词
何首乌/化学性与药物性肝损伤/信号传导Key words
Polygoni Multiflori Radix/Chemical and Drug Induced Liver Injury/Signal Transduction引用本文复制引用
梁子晗,李佳辉,程爽,袁卓雅,荣文雅,刘亚杰,郝玉洁,王睿林..何首乌致肝损伤的信号通路及其作用机制[J].临床肝胆病杂志,2024,40(3):626-632,7.基金项目
国家自然科学基金面上项目(81673806) （81673806）
中国医药教育协会2020重大科学攻关问题和医药技术难题(2020KTY001) National Natural Science Foundation of China(General Program)(81673806) （2020KTY001）
Major Scientific and Technological Issues and Challenges in Medicine and Pharmacy 2020 by the China Association of Medical Education(2020KTY001) （2020KTY001）
