农业生物技术学报2024，Vol.32Issue(4)：892-902,11.DOI:10.3969/j.issn.1674-7968.2024.04.014
IL-33/ST2信号通路影响干细胞功能的研究进展
Research Progress on the Effect of IL-33/ST2 Signaling Pathway on Stem Cell Function
摘要
Abstract
Interleucin 33(IL-33)is a cytokine with both pro-inflammatory and anti-inflammatory functions,and its signaling is mediated through its specific receptor suppressor of tumorigenicity 2(ST2).Activation of the IL-33/ST2 signaling pathway regulates NF-κb,TNFα,and Wnt signaling pathways depending on the cell type,thereby triggering inflammatory response and affecting the stemness and differentiation of stem cells.In this paper,the basic structure and composition of the IL-33/ST2 signaling pathway were reviewed,and the recent progress in stem cell function research was summarized.This review provides new ideas for the treatment of inflammatory and immune diseases by elucidating the mechanism of action of stem cells.关键词
IL-33/ST2信号通路/干细胞/癌症干细胞/细胞治疗/炎症Key words
IL-33/ST2 signaling pathway/Stem cell/Cancer stem cell/Cell therapy/Inflammation分类
农业科技引用本文复制引用
徐文杰,华进联..IL-33/ST2信号通路影响干细胞功能的研究进展[J].农业生物技术学报,2024,32(4):892-902,11.基金项目
国家自然科学基金(32072806 （）
32372970) （）
国家重点研发计划(2022YFD1302201) （2022YFD1302201）
陕西省重点研发计划(2022NY-044) （2022NY-044）
陕西省畜牧专项(20221086 （）
20230978) （）
