帕金森病睡眠障碍结构特征及其影响因素的临床研究OACSTPCD

Objective To investigate the incidence rate of sleep disorders,the features of sleep structure,and re-lated influencing factors in patients with Parkinson disease(PD).Methods A total of 101 patients with PD who attended the outpatient services or were hospitalized in Department of Neurology,The First Hospital of Hebei Medical University,from August 2016 to April 2022 were enrolled as subjects,and Unified Parkinson Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ)and Hoehn-Yahr(H-Y)staging were used to evaluate motor function and disease severity.The patients with PD were tested using Pittsburgh Sleep Quality Index(PSQI),Epworth Sleepiness Scale(ESS),International Restless Legs Scale(IRLS),and rapid eye movement sleep behavior disorder(RBD)scale,and related information was collected or mea-sured,including body height,body weight,body mass index(BMI),neck circumference,abdominal circumference,and past medical history.All patients received standardized nocturnal polysomnography(PSG).Results Among the 101 pa-tients with PD,87(86.14%)had sleep disorders.PSG showed that common sleep disorders included RBD,periodic limb movements(PLM),and obstructive sleep apnea-hypopnea syndrome(OSAHS).For the PD patients with RBD,the pro-portion of rapid eye movement sleep was(13.14±8.11)%,with poor subjective sleep quality and obvious depression.PLM was often comorbid with restless legs syndrome in PD patients.OSAHS was more likely to occur in PD patients with greater neck circumference and abdominal circumference,and there was no obvious association between OSAHS and BMI;in addition,excessive daytime sleepiness was more common in PD patients with OSAHS,which had a greater impact on the daytime function of the patents.Conclusion There is a relatively high incidence rate of sleep disorders in PD patients,and PD patients with sleep disorders often have the manifestations of RBD,PLM and OSAHS.PD patients with RBD tend to have poor sleep quality and obvious depression,and OSAHS is more likely to occur in PD patients with greater neck cir-cumference and abdominal circumference,which is not significantly associated with BMI.