中风与神经疾病杂志2024，Vol.41Issue(3)：259-263,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0051
不同脑小血管病负荷合并自发性高血压脑出血临床特征及预后相关性研究
Clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small ves-sel disease and their association with prognosis
摘要
Abstract
Objective To investigate the clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of cerebral small vessel disease(CSVD)and their association with prognosis.Methods A retrospective analysis was performed for the clinical data of the patients with hypertensive intracerebral hemorrhage who were hospitalized within 3 days after onset in Hebei Yanda Hospital from September 2017 to August 2021.Hematoma volume was calculated based on head CT scan results on admission;the severity of white matter hyperintensity,lacunae,enlarged perivascular spaces,and cerebral microbleeds was evaluated based on head MRI results after admission,and total CSVD score was calcu-lated.The clinical features of spontaneous hypertensive intracerebral hemorrhage with different loads of CSVD and their associa-tion with prognosis were analyzed.Results A total of 113 patients with cerebral hemorrhage were included,among whom there were 69 male patients and 44 female patients,with a mean age of(61.89±12.47)years.The univariate linear regression analysis showed that sex and systolic blood pressure were associated with bleeding volume,while total CVSD score was not asso-ciated with bleeding volume.The univariate linear regression analysis showed that hypertension,history of intracranial hemor-rhage,and total CVSD score were associated with NIHSS score on admission,and the multivariate logistic regression analysis showed that hypertension,history of intracranial hemorrhage,and total CVSD score were independent risk factors for high NIHSS score on admission.The univariate linear regression analysis showed that diabetes,smoking history,and total CVSD score were associated with MRS score on day 90 after discharge,and the multivariate logistic regression analysis showed that diabetes,smoking history,and total CVSD score were independent risk factors for poor prognosis.Conclusion The increase in total CSVD score may lead to the in-creases in the incidence rate of poor functional prognosis and NIHSS score on admission.关键词
高血压脑出血/脑小血管病负荷/临床特征/预后Key words
Hypertensive intracerebral hemor-rhage/Load of cerebral small vessel disease/Clinical features/Prognosis分类
医药卫生引用本文复制引用
郑占军,赵性泉..不同脑小血管病负荷合并自发性高血压脑出血临床特征及预后相关性研究[J].中风与神经疾病杂志,2024,41(3):259-263,5.基金项目
河北省廊坊市科技支撑计划项目 （）
