中国输血杂志2024，Vol.37Issue(3)：352-356,5.DOI:10.13303/j.cjbt.issn.1004-549x.2024.03.016
亚洲型DEL母亲产生抗-c致新生儿溶血病的母子输血救治
Hemolytic disease of the newborn caused by anti-c in puerperant of Asian-type DEL treated by transfusion:a case report
姚文娟 1高珺 1穆启明 1舒群峰2
作者信息
- 1. 湖北医药学院附属人民医院,湖北 十堰 442000
- 2. 十堰市中心血站
- 折叠
摘要
Abstract
Objective To explore a transfusion therapeutic plan for hemolytic disease of the newborn(HDN)caused by anti-c antibodies in mother of Asian-type DEL.Methods The ABO blood type and Rh phenotype of the mother and child were determined using the saline tube method.The mother′s RhD negativity was confirmed through classical anti-human globulin testing and RhD adsorption-elution test.The mother′s unexpected antibodies were screened and their titers were measured using classical anti-human globulin testing,antibody card test and polyamine method.Cross-matching was conduc-ted.The three hemolysis tests were performed by antibody card test.The mother′s RHD gene typing was conducted using a commercially available RHD negative identification gene detection kit(PCR-SSP method).Results The mother exhibited a CCee Rh serological phenotype,and the DEL gene test confirmed the presence of RHD?1227A,indicating the production of anti-c antibodies.The infant displayed a DCcEe Rh serological phenotype,positive for direct antiglobulin test and red cell elution.Based on the mother′s obstetric history,clinical manifestations of the infant and blood examination results,the diag-nosis was HDN caused by anti-c antibodies.Conclusion For infants with HDN caused by anti-c antibodies in mother of A-sian-type DEL,DCCee Rh phenotype red blood cell transfusion is recommended,while CCee Rh phenotype deglycerolized red blood cell transfusion is recommended for the mother.关键词
抗-c/亚洲型DEL/输血/新生儿溶血Key words
anti-c antibody/Asian-type DEL/blood transfusion/hemolytic disease of the newborn(HDN)分类
医药卫生引用本文复制引用
姚文娟,高珺,穆启明,舒群峰..亚洲型DEL母亲产生抗-c致新生儿溶血病的母子输血救治[J].中国输血杂志,2024,37(3):352-356,5.
