中国防痨杂志2024，Vol.46Issue(4)：479-484,6.DOI:10.19982/j.issn.1000-6621.20230452
CD4+和CD8+T细胞在结核病免疫应答中的作用
The role of CD4+and CD8+T cells in the immune response to tuberculosis
温淑芳 1魏荣荣 1李浩然 2刘毅1
作者信息
- 1. 首都医科大学附属北京胸科医院生物样本与数据资源库/北京市结核病胸部肿瘤研究所,北京 101149
- 2. 首都医科大学附属北京胸科医院细菌免疫室/北京市结核病胸部肿瘤研究所,北京 101149
- 折叠
摘要
Abstract
Tuberculosis(TB)caused by Mycobacterium tuberculosis(MTB)is the leading cause of death from a single infectious agent worldwide,and there has been a large number of individuals who remain in a long-term latent infection state after being infected.The clearance of MTB in the body primarily relies on specific immune responses,in which T lymphocytes,as the main cells involved in cellular immunity.Their proliferation and activation play a crucial role during the specific immune response in the body.This review discusses the functions of CD4+T cells and CD8+T cells,two subsets of T lymphocytes,in the immune response MTB infection,and summarizes the mechanisms of the immune response against MTB infection in the body.It aims to provide insights for further exploration of the adaptive immune network against MTB infection,diagnosis of TB,and the development of new vaccines in clinical research.关键词
结核/CD4阳性T淋巴细胞/CD8阳性T淋巴细胞/免疫/细胞因子Key words
Tuberculosis/CD4 positive T lymphocytes/CD8 positive T lymphocytes/Immunity/Cytokine分类
医药卫生引用本文复制引用
温淑芳,魏荣荣,李浩然,刘毅..CD4+和CD8+T细胞在结核病免疫应答中的作用[J].中国防痨杂志,2024,46(4):479-484,6.
