中国实用内科杂志2024，Vol.44Issue(3)：204-209,6.DOI:10.19538/j.nk2024030106
超声造影在糖尿病肾脏疾病鉴别诊断中的价值研究
Study on the value of contrast-enhanced ultrasound in the differential diagnosis of diabetic kidney disease
摘要
Abstract
Objective To investigate the clinical value of contrast-enhanced ultrasound(CEUS)in the early differential diagnosis of diabetic kidney disease(DKD).Methods The clinical data of patients with chronic kidney disease(CKD)hospitalized in Beijing Air Force Medical Center from August 2021 to October 2022 were collected,including the etiology of CKD,ultrasound parameters and laboratory biochemical indicators.The patients were divided into non-DKD group and DKD group.The differences in ultrasound parameters between the two groups were compared and their correlation with clinical indicators were analyze.Results The resistance index(RI)of renal portal artery in DKD group(0.72±0.08)was higher than that in non-DKD group(0.66±0.07)(t=-3.52,P＜0.001),the RI of segmental artery in DKD group(0.67± 0.06)was higher than that in non-DKD group(0.62±0.07)(t=-2.93,P=0.005),and the time to peak(TTP)[(23.37±6.68)s]of contrast medium was longer than that in non-DKD group[(19.57±7.81)s](t=-2.14,P=0.036),while there were no statistically significant differences in RI of interlobar artery and contrast parameters such as arrival time(AT),ascending slope(AS),peak intensity(PI),descending slope(DS),area under curve(AUC)and mean transit time(MTT)(P＞0.05).During the period of eGFR≥60 mU(min·1.73 m2),the RI of renal portal artery(0.70±0.08),segmental artery(0.65±0.06)and interlobar artery(0.61±0.05)in DKD group was significantly higher than that in non-DKD group[(0.62±0.10)(t=-3.30,P＜0.01),(0.59±0.05)(t=-3.29,P＜0.01),(0.56±0.04)(t=-3.05,P＜0.01)].The TTP in DKD group[(23.67±3.75)s]was also significantly longer than that in non-DKD group[(18.80±7.10)s](t=-2.54,P＜0.05).During the period of eGFR＜60 mL/(min·1.73m2),compared with non-DKD group,the RI of renal portal artery in DKD group(0.75±0.06)was higher(t=-2.74,P＜0.01),but there were no differences in RI of segmental artery,RI of interlobar artery,or TTP.Conclusions The TTP combined with RI of segmental artery,interlobar artery,and renal portal artery in CEUS has certain clinical value in the early differential diagnosis of diabetic kidney disease.关键词
糖尿病性肾脏疾病/慢性肾脏病/超声造影/肾功能Key words
diabetic kidney disease/chronic kidney disease/contrast-enhanced ultrasound/renal function分类
医药卫生引用本文复制引用
凌晓晶,李玥铭,刘东,范校周,高卓,余颖,谷君辉,单婧,崔瑜,吕小萌,邱德俊..超声造影在糖尿病肾脏疾病鉴别诊断中的价值研究[J].中国实用内科杂志,2024,44(3):204-209,6.基金项目
国家军用标准研究项目(BKJ20B047) （BKJ20B047）
空军特色医学中心科技助推课题(2022ZTYB46) （2022ZTYB46）
空军特色医学中心临床研究项目(2021LC006) （2021LC006）
