苹果酸奈诺沙星胶囊治疗腹膜透析相关性导管感染的疗效分析OA北大核心CSTPCD

Objective To observe the efficacy and safety of Nemonoxacin Malate capsule in the treatment of peritoneal dialysis-associated catheter infection.Methods Select cases receiving treatment from March 1,2018 to December 31,2021,who had suffered from peritoneal dialysis-associated exit-site infections or tunnel infections and received treatment of Nemonoxacin Malate capsules and regular follow-up in the Peritoneal Dialysis Center of the First Affiliated Hospital of China Medical University.The basic data of patients were collected to record the score of exit-site infection and infection-related indicators.The treatment effect on peritoneal dialysis associated catheter infection in patients taking Nemonoxacin Malate capsules was retrospectively analyzed through a before-and-after self-controlled design.Results A total of 23 patients with peritoneal dialysis-related catheter infection were included,who were treated with Nemonoxacin Malate capsules.Totally 29 episodes of catheter infection occurred in 23 patients,and Staphylococcus aureus was the most predominant pathogen(52.2％).The score of exit-site infection of 21 patients(91.3％)decreased to the normal range after the application of Nemonoxacin Malate capsules,the score of two patients(8.7％)was still not up to the standard after three weeks of treatment with Nemonoxacin Malate capsules,and 23 patients(100％)had a lower score of exit-site infection than before the application of Nemonoxacin Malate capsules.All patients had no serious adverse reactions.Conclusion Nemonoxacin Malate capsule is safe and effective in the treatment of peritoneal dialysis-related catheter infection.