中国中西医结合影像学杂志2024，Vol.22Issue(2)：143-148,6.DOI:10.3969/j.issn.1672-0512.2024.02.004
不同MoCA评分下血管性认知障碍患者的灰质体积差异基于体素的形态学分析
A voxel-based morphometry(VBM)study of gray matter volume in patients with vascular cognitive impairment according to different MoCA scores
摘要
Abstract
Objective:To explore the relationship of the gray matter volume and the degree of cognitive impairment in patients with vascular cognitive impairment(VCI)by the voxel-based morphometry(VBM)method.Methods:A total of 157 VCI patients were divided into the mild,moderate and severe groups based on the score of Montreal Cognitive Assessment(MoCA).All patients underwent MRI scan and VBM analysis.Finally,the volumes of total intracranial,gray matter,white matter,ventricle/cerebrospinal fluid and the ratio of the gray/white matter volume to the total intracranial volume were compared among the three groups.The correlations between gray matter volumes of different brain regions and MoCA score were analyzed.Results:Compared with the mild group,the gray matter volumes in the right inferior temporal gyrus,right middle temporal gyrus,right middle frontal gyrus,right inferior frontal gyrus,right hippocampus,right supplementary motor area and left paracentral lobule were significantly lower in the severe group(all P＜0.05).There was a positive correlation between gray matter volume and MoCA score(r=0.249,P＜0.001).The gray matter volume in the right hippocampus was positively correlated with the MoCA score(r=0.432,P＜0.001).Conclusions:VCI patients with different levels of cognitive impairment have gray matter volume changes in the frontal lobe,temporal lobe,parietal lobe and hippocampus.From the perspective of gray matter volume differences,this study provides neuroimaging evidence supporting the classification to the degree of cognitive impairment.关键词
血管性认知障碍/灰质/蒙特利尔认知量表/基于体素的形态学测量/磁共振成像Key words
Vascular dementia/Gray matter/Montreal Cognitive Scale/Voxel-based morphometry/Magnetic resonance imaging引用本文复制引用
李凯琳,魏翔宇..不同MoCA评分下血管性认知障碍患者的灰质体积差异基于体素的形态学分析[J].中国中西医结合影像学杂志,2024,22(2):143-148,6.基金项目
国家自然科学基金青年项目(82205267). （82205267）
