中国中西医结合影像学杂志2024，Vol.22Issue(2)：149-154,6.DOI:10.3969/j.issn.1672-0512.2024.02.005
基于独立成分分析对伴脑室周围白质损伤的痉挛型脑性瘫痪患儿脑功能网络的研究
An independent component analysis-based study of functional brain networks in children with spastic cerebral palsy complicated with periventricular white matter injury
摘要
Abstract
Objective:To investigate intra-and internetwork functional connectivity changes in children with spastic cerebral palsy(SCP)complicated with periventricular white matter injury(PWMI)using independent component analysis(ICA).Methods:Resting-state fMRI was performed on 28 SCP children with PWMI(the SCP group)and 19 normal children(the control group).The ICA method was applied to extract the network components of the two groups,and SPM12 and NBS software were used to compare the differences in intra-and internetwork functional connectivity between the two groups,and Pearson or Spearman correlation analysis were applied to verify the correlation between functional connectivity differences and clinical variables in the SCP group.Results:Compared with the control group,the functional connectivity of the left middle frontal gyrus,left precuneus and right angular gyrus within the default mode network,the right postcentral gyrus within the ventral attention network,and the bilateral lingual gyrus within the medial visual network were weakened in the patient group,but no significant correlations were found between the above functional connectivity difference and clinical variables.Conclusions:Patients with SCP have abnormal functional brain network patterns,and it is hypothesized that alterations in functional conectivity may serve as an imaging bioindicator for early diagnosis and recognition of SCP.关键词
脑室周围白质损伤/痉挛型脑性瘫痪/独立成分分析/磁共振成像Key words
Periventricular white matter injury/Spastic cerebral palsy/Independent component analysis/Magnetic resonance imaging引用本文复制引用
赵纯风,罗丹,喻皓月,彭莹,杨艳丽,刘衡..基于独立成分分析对伴脑室周围白质损伤的痉挛型脑性瘫痪患儿脑功能网络的研究[J].中国中西医结合影像学杂志,2024,22(2):149-154,6.基金项目
国家自然科学基金青年科学基金项目(81901732). （81901732）
