中国中西医结合影像学杂志2024，Vol.22Issue(2)：154-159,6.DOI:10.3969/j.issn.1672-0512.2024.02.006
基于图论分析法对难治性癫痫脑功能网络的研究
Study of the brain functional network in intractable epilepsy based on graph theory analysis
摘要
Abstract
Objective:To study the changes in topological properties of the brain functional network in children with intractable epilepsy(ITE)based on resting-state fMRI(rs-fMRI)and graph theory analysis.To analyze the correlations between abnormal network topological parameters and duration,intelligence quotient.To explore the brain functional network changes in ITE patients.Methods:A total of 23 ITE children(the ITE group)and 23 healthy volunteers(the control group)were recruited.T2-FLAIR,3D-T1WI and rs-fMRI were performed in all subjects.GRETNA V2.0 software was used to preprocess the acquired data and calculate the network topological parameters,and SPSS 18.0 software was used to analyze the differences between groups.Results:There were no significant differences in age,gender and education years between the two groups(all P＞0.05).The brain networks of the ITE group and the control group exhibited small-world characteristics.The local efficiency and standardized clustering coefficient of the ITE group were lower than those of the control group(P=0.014,0.027).Abnormal brain areas in the ITE group were mainly located in the default mode network and visual cortex.Correlation analysis revealed that the nodal degree centrality of the left precuneus and the nodal efficiency of the left precuneus in the ITE group were negatively correlated with duration(r=-0.564,P=0.005;r=-0.539,P=0.008).Conclusions:The global and node topological properties of the brain functional network of ITE are abnormal,and the main change in the functional network is a decrease in local separation function,providing a new perspective for the study of brain functional networks in ITE.关键词
难治性癫痫/功能磁共振成像/静息态/图论分析Key words
Intractable epilepsy/Functional magnetic reso-nance imaging/Resting state/Graph theory analysis引用本文复制引用
唐文英,李旭虹,曾珍,李文富,张体江..基于图论分析法对难治性癫痫脑功能网络的研究[J].中国中西医结合影像学杂志,2024,22(2):154-159,6.基金项目
国家自然科学基金面上项目(82171919) （82171919）
贵州省高等学校智能医学影像工程研究中心(黔教技[2023]038) （黔教技[2023]038）
遵义市科技计划项目(遵市科合HZ字[2023]280号) （遵市科合HZ字[2023]280号）
贵州省教育厅高等学校科学研究项目(青年项目)(黔教技[2022]230号). （青年项目）
