中国中西医结合影像学杂志2024，Vol.22Issue(2)：180-183,4.DOI:10.3969/j.issn.1672-0512.2024.02.011
基于肺腺癌脑转移瘤CT灌注成像参数对肺腺癌EGFR基因突变状态预测的初步研究
A preliminary study on the prediction of EGFR gene mutation status in lung adenocarcinoma based on CT perfusion imaging parameters of brain metastases
摘要
Abstract
Objective:To apply CT perfusion imaging parameters of brain metastases in patients with lung adenocarcinoma to classify the mutation status of the epidermal growth factor receptor(EGFR)gene.Methods:Forty-five patients with brain metastases in lung adenocarcinoma were retrospectively analyzed,26 cases were EGFR mutation and 19 cases were EGFR wild-type.All patients underwent cranial CT perfusion imaging,and CT perfusion parameters from the enhanced tumor and peritumoral edema were extracted.Perfusion parameters with significant correlations were applied to classify EGFR mutation and ROC curve was used to assess the efficiency.Results:Among the perfusion parameters,cerebral blood flow(CBF)and mean transit time(MTT)had significant differences between EGFR mutation and the wild-type(both P＜0.005).The AUC of the CBF and MTT comodeling for classifying EGFR mutation status was 0.790.Conclusion:CT perfusion imaging parameters of brain metastases in patients with primary lung adenocarcinoma can be used to classify EGFR mutation status.关键词
体层摄影术,X线计算机/灌注成像/脑转移瘤/表皮生长因子受体/基因突变Key words
Tomography,X-ray computed/Perfusion imaging/Brain metastases/Epidermal growth factor receptor/Gene mutation引用本文复制引用
姜春成,姜中华,刘歆,曲倩倩,王云强..基于肺腺癌脑转移瘤CT灌注成像参数对肺腺癌EGFR基因突变状态预测的初步研究[J].中国中西医结合影像学杂志,2024,22(2):180-183,4.基金项目
烟台市科技计划项目(2022YD091,2020YD053). （2022YD091,2020YD053）
