中国中西医结合影像学杂志2024，Vol.22Issue(2)：127-132,6.DOI:10.3969/j.issn.1672-0512.2024.02.001
分形维数对高级别胶质瘤异柠檬酸脱氢酶-1基因突变状态和Ki-67指数的评估价值
Value of fractal dimension in evaluating IDH-1 mutation status and Ki-67 index of high-grade gliomas
摘要
Abstract
Objective:To analyze the value of fractal dimension(FD)in evaluating the mutation status and proliferation activity of IDH-1 gene of high grade gliomas(HGG).Methods:A total of 75 patients with HGG confirmed by pathology were included,and IDH-1 status and Ki-67 index were tested,and 52 cases were IDH-1 wild-type and 23 cases were IDH-1 mutation-type.The tumor and the peritumoral edema were automatically delineated at the maximum level and above and below the maximum level on the preoperative T1WI,T2WI and DWI,respectively.The FD values at the outer edge were determined,and the FD value at the three levels was averaged as the measured value.The difference of FD values between the IDH-1 wild-type group and the mutation-type group was compared,and the ROC curve was used to analyze the efficacy of FD value for evaluating IDH-1 mutation.Logistics regression was used to analyze whether FD value was an independent risk factor for IDH-1 mutation,and Pearson correlation analysis was used to evaluate the relationship between different FD values and Ki-67 index.Results:The FD values of tumors on T1WI,T2WI and DWI and the FD value of peritumoral edema on T2WI in the IDH-1 wild-type group were lower than those in the IDH-1 mutation-type group(all P＜0.05).The FD value on DWI had the highest diagnostic efficiency,with an AUC of 0.868,a specificity of 0.696,and a sensitivity of 0.923,and the FD value of tumor on DWI was an independent risk factor for IDH-1 mutation prediction.All FD values were positively correlated with Ki-67 indices,and the correlation between the FD value of peritumoral edema measured on T2WI and Ki-67 index was the strongest(r=0.485 3,P＜0.000 1).Conclusions:FD value based on MRI can be used to evaluate the IDH-1 mutation status in HGG patients,and it is positively correlated with Ki-67 index.关键词
胶质瘤/异柠檬酸脱氢酶/基因突变/Ki-67指数/分形维数/磁共振成像Key words
Glioma/Isocitrate dehydrogenase/Gene mutation mutation/Ki-67 index/Fractal dimension/Magnetic resonance imaging引用本文复制引用
席华泽,周俊林..分形维数对高级别胶质瘤异柠檬酸脱氢酶-1基因突变状态和Ki-67指数的评估价值[J].中国中西医结合影像学杂志,2024,22(2):127-132,6.基金项目
国家自然科学基金面上项目(82071872). （82071872）
