中国中西医结合影像学杂志2024，Vol.22Issue(2)：138-143,6.DOI:10.3969/j.issn.1672-0512.2024.02.003
原发性失眠相关情绪障碍的低频振幅静息态fMRI研究
A resting-state fMRI study of alterations in amplitude of low-frequency fluctuation in primary insomnia patients with emotional disorders
摘要
Abstract
Objective:To investigate the changes of brain nerve activity in primary insomnia patients with emotional disorders.Methods:Twenty primary insomnia patients(the insomnia group)and 20 healthy subjects(the control group)were recruited and subjected to resting-state fMRI.The amplitude of low-frequency fluctuation(ALFF)values were compared between the two groups and the correlations between ALFF values and the evaluation scales were analyzed.Results:The Pittsburgh sleep quality index(PSQI),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)scores in the insomnia group were significantly different from those in the control group(all P＜0.05).Compared with the control group,the primary insomnia group showed increased ALFF values in the left inferior temporal gyrus,right orbitofrontal cortex,right anterior cingulate,right middle temporal gyrus,bilateral superior frontal gyrus,right superior occipital gyrus and left posterior central gyrus,and decreased ALFF values in the left middle cingulate,left middle frontal gyrus and right superior frontal gyrus(P＜0.01,AlphaSim corrected).Furthermore,the SDS scores were positive correled with ALFF values in the right orbitofrontal cortex and left cingulate gyrus(r=0.528,0.641,both P＜0.05),and the SAS score had a positive correlation with ALFF value in the left cingulate gyrus(r=0.494,P=0.037).Conclusions:The changes of brain nerve activity in primary insomnia patients with emotional disorders can be analyzed by ALFF,mainly the abnormal spontaneous brain activity in the brain regions related to emotion-cognition(cingulate gyrus,orbitofertal cortex,etc.),and the spontaneous brain activity in some brain regions is correlated with clinical indicators.Abnormal spontaneous activity could be an efficient neuroimaging biomarker for primary insomnia and could establish a foundation for the assessment of disease severity and treatment recommendations.关键词
原发性失眠/磁共振成像/低频振幅Key words
Primary insomnia/Magnetic resonance imaging/Amplitude of low-frequency fluctuation引用本文复制引用
王忠艳,霍健伟,付清楠,陈鹏..原发性失眠相关情绪障碍的低频振幅静息态fMRI研究[J].中国中西医结合影像学杂志,2024,22(2):138-143,6.基金项目
北京市属医院科研培育项目(PZ202014). （PZ202014）
