产后女性脑镜像同伦功能连接改变的静息态fMRI研究OA北大核心CSTPCD

Objective:Voxel-mirrored homotopic connectivity(VMHC)was used to study the difference of functional connection between parity points in the brain of postpartum women and nulliparous women to explore the changes of brain function of postpartum women.Materials and Methods:The resting-state functional magnetic resonance imaging(rs-fMRI)data and structural image data of 39 postpartum women and 26 nulliparous women were collected for VMHC analysis,and the differences of VMHC between groups were analyzed by a two-sample t-test.Moreover,the demographic data and Interpersonal Reactivity Index-C(IRI-C)scores of the two groups were collected.Results:The analysis of the IRI-C scale found a significant difference in empathy between postpartum women and nulliparous women(P<0.001).Compared with the nulliparous women,the postpartum women showed significantly decreased VMHC in bilateral fusiform gyrus,parahippocampal gyrus,middle frontal gyrus,medial frontal gyrus,anterior central gyrus,putamen and lentiform nucleus and other brain regions(FDR corrected,voxel level P<0.001,cluster level P<0.05,two tailed),while they showed significantly increased VMHC in bilateral precuneus,parietal lobules and subparietal lobules(FDR corrected,voxel level P<0.01,cluster level P<0.05,two tailed).Conclusions:After giving birth for the first time,the functional connections between hemispheres in some brain regions of women have changed,which may be the adaptive changes of women's parenting behavior during the postpartum period.