磁共振成像2024，Vol.15Issue(3)：56-61,6.DOI:10.12015/issn.1674-8034.2024.03.010
4D-Flow MRI在肥厚型心肌病左室流出道血流评估中的价值探索
Value of 4D-Flow MRI in evaluating left ventricular outflow tract peak velocity in hypertrophic cardiomyopathy:A proof-of-concept study
摘要
Abstract
Objective:To explore the feasibility of using four-dimensional flow(4D-Flow)magnetic resonance imaging(MRI)in left ventricle,and to evaluate the reproducibility and consistency of quantification of left ventricular outflow tract(LVOT)peak velocity by comparing with two-dimensional flow(2D-Flow)MRI and echocardiography.Materials and Methods:This research was a prospective and cross-sectional study.Twenty-one patients with hypertrophic cardiomyopathy(HCM)underwent cardiac MRI 2D-Flow and 4D-Flow data acquisition on a 3.0 T MRI scanner August 2022 to January 2023.Echocardiography within one weeks before or after MRI examination were collected.The inter-class correlation coefficient(ICC),coefficient of variation(COV)and Bland-Altman analysis were used to evaluate the reproducibility and consistency of LVOT peak velocity derived from 2D-Flow and 4D-Flow,and the relationship between 2D/4D-Flow and echocardiography was analyzed by Pearson correlation analysis.Results:The ICC of 2D-Flow and 4D-Flow were 0.999/0.999 and 0.995/0.992,respectively,and the COV of 2D-Flow and 4D-Flow were 0.5%/0.5%and 2.4%/2.6%,respectively.4D-Flow was moderately correlated with echocardiography(r=0.574,P=0.006),but the consistency between the two was poor(ICC= 0.375,P=0.013).Besides,there were no significant consistency and correlation between 2D-Flow and 4D-Flow/echocardiography.Conclusions:4D-Flow cardiac MRI can visualize the flow patterns within the heart.The peak velocity of LVOT derived from 4D-Flow is highly reproducible and is significantly correlated with echocardiography.关键词
肥厚型心肌病/四维血流/二维血流/心脏磁共振/磁共振成像Key words
hypertrophic cardiomyopathy/four-dimensional flow/two-dimensional flow/cardiac magnetic resonance/magnetic resonance imaging分类
医药卫生引用本文复制引用
徐晶,陈秀玉,尹刚,闫伟鹏,陆敏杰,赵世华..4D-Flow MRI在肥厚型心肌病左室流出道血流评估中的价值探索[J].磁共振成像,2024,15(3):56-61,6.基金项目
National Key R&D Program of China(No.2021YFF0501400,2021YFF0501404) （No.2021YFF0501400,2021YFF0501404）
National Natural Science Foundation of China(No.81930044) （No.81930044）
Youth Key Program of High-level Hospital Clinical Research(No.2022-GSP-QZ-5). 国家重点研发计划项目(编号:2021YFF0501400、2021YFF0501404) （No.2022-GSP-QZ-5）
国家自然科学基金项目(编号:81930044) （编号:81930044）
高水平医院临床科研青年重点项目(编号:2022-GSP-QZ-5) （编号:2022-GSP-QZ-5）
