磁共振成像2024，Vol.15Issue(3)：200-205,6.DOI:10.12015/issn.1674-8034.2024.03.033
多模态磁共振成像技术在深部脑刺激治疗帕金森病中的研究进展
Research progress of multimodal MRI in deep brain stimulation therapy for Parkinson's disease
摘要
Abstract
Parkinson's disease(PD),which is characterized by resting tremor,muscular tonus,bradykinesia,and postural balance abnormalities,is the second most prevalent neurodegenerative disease in middle-aged and older persons worldwide.Its incidence is expected to increase to double in the following three decades.As the negative effects of medicines become increasingly evident,deep brain stimulation(DBS)has gained popularity as a novel type of adjuvant therapy.Magnetic resonance imaging(MRI)can non-invasively provide information on the structure,function,and metabolism of brain tissues in vivo,which is of greater clinical significance for assessing the effects of DBS after treatment of PD and guiding therapy.Therefore,this article provides a review of the research progress of multimodal MRI,including structural magnetic resonance imaging(sMRI),diffusion tensor imaging(DTI),blood oxygenation level dependent-functional magnetic resonance imaging(BOLD-fMRI),susceptibility-weighted imaging(SWI),quantitative magnetic susceptibility mapping(QSM),and magnetic resonance spectroscopy(MRS)in the treatment of PD with DBS,with the aim of assisting the clinic in choosing efficient and safe treatment methods and correctly evaluating the therapeutic effects.关键词
帕金森病/磁共振成像/深部脑刺激/脑结构/脑功能Key words
Parkinson's disease/magnetic resonance imaging/deep brain stimulation/brain structure/brain function分类
医药卫生引用本文复制引用
刘苗苗,刘泉源,任庆发,徐东昊,李祥林..多模态磁共振成像技术在深部脑刺激治疗帕金森病中的研究进展[J].磁共振成像,2024,15(3):200-205,6.基金项目
Key R&D Plan of Shandong Province of China(No.2018YFJH0501). 山东省重点研发计划(编号:2018YFJH0501) （No.2018YFJH0501）
