广东医学2024，Vol.45Issue(2)：166-170,5.DOI:10.13820/j.cnki.gdyx.20230624
早产儿支气管肺发育不良及远期肺功能与出生时维生素D水平的关系
A study on the correlations between bronchopulmonary dysplasia in preterm infants,long-term pulmonary function,and vitamin d levels at birth
摘要
Abstract
Objective To analyze the relationship between vitamin D levels at birth and the development of bron-chopulmonary dysplasia(BPD)and long-term pulmonary function in preterm infants.Methods A total of 120 preterm infants admitted to the neonatal intensive care unit(NICU)between June 2018 and March 2020 were included in this study.Serum vitamin D levels were measured in all preterm infants at birth.Follow-up assessments were conducted when the infants reached 2 years of age,during which pulmonary function parameters,including TPTEF/TE,VPTEF/VE,and PEF,were measured.Spearman correlation analysis was used to assess the relationship between serum vitamin D levels and the development of BPD,while Pearson correlation analysis was used to evaluate the association between serum vita-min D levels at birth and pulmonary function parameters at 2 years of age.Results Compared to preterm infants in the non-BPD group,those in the BPD group had significantly lower serum vitamin D levels(P＜0.05).Serum vitamin D levels varied significantly among infants with different BPD severity levels(P＜0.05),with progressively lower levels ob-served in more severe cases.At 2 years of age,preterm infants in the BPD group exhibited significantly lower pulmonary function parameters,including TPTEF/TE,VPTEF/VE,and PEF,compared to those in the non-BPD group(P＜0.05).Significant differences in these pulmonary function parameters were also observed among infants with varying BPD severity levels(P＜0.05),with greater disease severity corresponding to lower pulmonary function parameters.There was a significant negative correlation between serum vitamin D levels at birth and the development of BPD(r=-0.659,P＜0.05).Moreover,serum vitamin D levels at birth were positively correlated with pulmonary function parameters at 2 years of age,including TPTEF/TE,VPTEF/TE,and PEF(r=0.254,0.232,0.265,P＜0.05).Conclusion Serum vita-min D levels at birth are closely associated with the development of BPD and long-term pulmonary function in preterm in-fants.Vitamin D deficiency at birth can be used to assess the progression of BPD and predict the long-term prognosis of affected infants.关键词
早产儿/支气管肺发育不良/肺功能/维生素DKey words
preterm infants/bronchopulmonary dysplasia/lung function/vitamin D分类
医药卫生引用本文复制引用
卢田甜,麦文慧,王丹虹,刘敏,陈秀灵,贾雁平..早产儿支气管肺发育不良及远期肺功能与出生时维生素D水平的关系[J].广东医学,2024,45(2):166-170,5.基金项目
海南省自然科学基金青年基金项目(819QN388) （819QN388）
