广东医学2024，Vol.45Issue(3)：301-305,5.DOI:10.13820/j.cnki.gdyx.20234056
缺铁性贫血与结直肠癌发病风险的孟德尔随机化研究
Relationship between iron deficiency anemia and colorectal cancer:evidence from Mendelian randomization anal-ysis
摘要
Abstract
Objective This study aimed to explore the causal relationship between iron deficiency anemia(IDA)and the risk of colorectal cancer(CRC)using Mendelian randomization(MR)analysis.Methods Data on IDA and CRC were obtained from the UK Biobank database.The inverse variance-weighted(IVW)method was used as the main analytical tool,and weighted median(WM)and MR-Egger regression were used as supplementary analytical methods.Cochran's Q test and MR-Egger regression outcomes were used for sensitivity analysis to ensure the reliability of the re-sults.Results The IVW analysis showed a causal relationship between IDA and CRC(OR=1.284,95％CI:1.037-1.591,P=0.022).Sensitivity analysis further confirmed the consistency and reliability of the analytical results.Conclu-sion There is a causal relationship between IDA and CRC,laying the foundation for further research on the relationship between IDA and the development of CRC.This study aims to explore the causal relationship between iron deficiency ane-mia and the risk of colorectal cancer using the Mendelian randomization approach.关键词
缺铁性贫血/结直肠癌/孟德尔随机化Key words
iron-deficiency anemia/colorectal cancer/Mendelian randomization分类
医药卫生引用本文复制引用
宿茂伟,钟隆柱,胡佳,吴宏适..缺铁性贫血与结直肠癌发病风险的孟德尔随机化研究[J].广东医学,2024,45(3):301-305,5.基金项目
国家自然科学基金资助项目(82100890) （82100890）
广州市荔湾区科技计划项目(20230707) （20230707）
