广东医学2024，Vol.45Issue(3)：391-396,6.DOI:10.13820/j.cnki.gdyx.20232547
三阴性乳腺癌肿瘤免疫抑制机制研究进展
Advances in research on tumor immune suppression mechanisms in triple-negative breast cancer
摘要
Abstract
Triple-negative breast cancer(TNBC)is a molecular subtype of breast cancer characterized by poor differentiation,high invasiveness,and poor prognosis.Due to the lack of estrogen,progesterone receptors,and human ep-idermal growth factor receptor 2,endocrine therapy and targeted therapy are ineffective,and chemotherapy remains the main treatment option.In order to improve the survival of TNBC patients,immunotherapy,as an emerging treatment method,has made significant progress in TNBC,but long-term benefits are still unclear.This article comprehensively reviews the mechanisms of immune suppression microenvironment formation in TNBC from the perspectives of immune cells,inflamma-tory signaling pathways,and epigenetic factors,based on the latest research findings,providing a theoretical basis for targeted therapies to reverse immune suppression.关键词
三阴性乳腺癌/免疫抑制/免疫细胞/炎症信号通路/表观遗传Key words
triple-negative breast cancer/immunosuppression/immune cells/inflammatory signaling pathway/epigenetic factor分类
医药卫生引用本文复制引用
黄群星,陈天文..三阴性乳腺癌肿瘤免疫抑制机制研究进展[J].广东医学,2024,45(3):391-396,6.基金项目
深圳市科技计划项目(SGDX20211123141201002) （SGDX20211123141201002）
