血清1-磷酸鞘氨醇联合透明质酸检测对结直肠癌的诊断及预后价值OACSTPCD

Objective:To investigate the clinical significance of serum sphingosine 1-phosphate(S1P)and hyaluronan(HA)alterations in individuals diagnosed with colorectal cancer(CRC).Methods:Clinical data of 47 patients with colorectal cancer(the colorectal cancer group),30 patients with benign intestinal disease(the benign disease group)and 38 healthy subjects(the healthy control group)were collected,and serum S1P and HA levels were detected in all subjects.Spearman correlation analysis was used to evaluate the correlation between the two.The efficacy of serum S1P,HA,carcinoembryonic antigen(CEA),and carbohydrate antigen 19-9(CA19-9)alone and in combination was analyzed using receiver operating characteristic(ROC)curves.Results:Se-rum S1P levels were increased successively in the healthy control group,benign disease group and colorectal cancer group(P<0.05).The serum HA level in the colorectal cancer group was higher than that in the healthy control group(P<0.05),but there was no statistically significant difference between the serum HA level in benign disease group and that in the colorectal cancer group and the healthy control group(P>0.05).Spearman correlation analysis showed that serum S1P was positively correlated with HA in the colorectal cancer group(r=0.406,P<0.05).The results of the ROC curve showed that the areas under the curve for the diagnosis of CRC were 0.871,0.642,0.694,0.593,and 0.916 for S1P,HA,CEA,and CA19-9 alone and in combina-tion,respectively.Postoperative serum HA levels were significantly lower in colorectal cancer patients(P<0.001),while the dif-ference between postoperative serum S1P levels and preoperative levels was not statistically significant(P>0.05).Conclusion:The combined detection of serum S1P and HA has a certain clinical value in the auxiliary diagnosis and efficacy monitoring of colorectal cancer.