海南医学院学报2024，Vol.30Issue(6)：421-427,7.DOI:10.13210/j.cnki.jhmu.20231215.001
ABCG2、PDZK1、SLC22A12基因交互效应与乌鲁木齐市汉族男性高尿酸血症的关联性研究
Association of ABCG2,PDZK1,SLC22A12 gene polymorphisms with hyperuricemia in the males of Han ethnic group in Urumqi
摘要
Abstract
Objective:To investigate the association between rs2231142 locus of ABCG2 gene,rs12129861 locus of PDZK1 gene and rs505802 locus of SLC22A12 gene and hyperuricemia in the males of Han ethnic group in Urumqi.Methods:A total of 334 males of Han ethnic group with hyperuricemia who visited the First Affiliated Hospital of Xinjiang Medical University were selected as the hyperuricemia group,and 488 healthy males of Han ethnic group from the same hospital were selected as the control group.Peripheral venous blood samples were obtained to biochemical indicators.Genetic testing was performed using mul-tiple ligase detection reactions,and the association between different genotypes of ABCG2,PDZK1,SLC22A12 and hyperurice-mia was analyzed.Results:The blood urea nitrogen,creatinine,triglyceride,high density lipoprotein(HDL),low density lipo-protein(LDL),diastolic blood pressure and the BMI of both groups were significantly higher than that of the control group(P<0.05);no notable disparities were observed in terms of age.There were no appreciable variations in blood glucose and systolic blood pressure between the two groups(P>0.05).Following adjusting for age,regular exercise and other confounding factors,multivariate unconditional logistic regression analysis showed that the rs12129861 and rs2231142 genotypes in the Urumqi Han population with hyperuricemia were significantly different from the control group(P<0.05).Individuals with the GT+TT geno-type of ABCG2 gene were observed to have a 1.767 times increased risk of hyperuricemia compared to the control group(95%CI:1.332,2.343,P<0.05).Individuals with the GA+AA genotype of the PDZK1 gene were found to have a 0.649 times greater risk of hyperuricemia compared to the control group(95%CI:0.484,0.810,P<0.05).Interaction analysis revealed an association be-tween these three loci interactions and the development of hyperuricemia(P<0.05).There was no significant association between rs505802 genotype and hyperuricemia(P<0.05).Conclusion:The rs2231142 locus of ABCG2 gene and rs12129861 locus of PDZK1 gene are the main risk factors for hyperuricemia in Urumqi Han male population(P<0.05).Allele T may be a risk factor for hyperuricemia,while allele A may be a protective factor.关键词
高尿酸血症/基因多态性/危险因素/关联性分析Key words
Hyperuricemia/Genetic polymorphisms/Risk factor/Association analysis分类
医药卫生引用本文复制引用
李珍珍,陈昱名,刘璐,何爽,夏依代·图尔荪,苗蕾..ABCG2、PDZK1、SLC22A12基因交互效应与乌鲁木齐市汉族男性高尿酸血症的关联性研究[J].海南医学院学报,2024,30(6):421-427,7.基金项目
This study was supported by National Natural Science Foundation of China(81460153) 国家自然科学基金资助项目(81460153) （81460153）
