海南医学院学报2024，Vol.30Issue(6)：451-462,12.DOI:10.13210/j.cnki.jhmu.20230612.002
基于动物实验系统评价大黄素治疗糖尿病肾病的可行性
Evaluation of the feasibility of emodin in the treatment of diabetic nephropathy based on animal experimental system
摘要
Abstract
Objective:To systematically evaluate the protective effect of emodin on the kidney of diabetes nephropathy ani-mals.Methods:The databases of CNKI,VIP,Wanfang,Chinese biomedical literature and PubMed were searched by computer,and the animal experiments of emodin in the treatment of diabetes nephropathy from the establishment of the database to February 25,2023 were searched.RevMan 5.4.1 software was used for analysis.Results:Totally 12 studies were included.The results showed that compared with the control group,the emodin group was more effective in reducing blood glucose[SMD=-2.51,95%CI(-3.77,-1.24),I2=89%],creatinine[SMD=-3.05,95%CI(-4.75,-1.34),I2=91%],urea nitrogen[SMD=-2.69,95%CI(-3.88,-1.50),I2=82%],24 h urine protein quantification[SMD=-3.35,95%CI(-4.85,-1.85),I2= 87%],relative kidney weight[SMD =-7.72,95%CI(-12.55,-2.88),I2=90%],triacylglycerol[SMD=-1.24,95%CI(-1.94,-0.54),I2=0%]and other indicators.There was no significant difference between the emodin and control groups in cho-lesterol[SMD=-1.19,95%CI(-2.29,-0.55),I2=77%].At the same time,meta-analysis showed that emodin protection of kidney was related to the expression of nephrin and related signal pathways.Few serious adverse reactions related to such studies have been reported.Conclusion:Emodin has a protective effect on the kidney of diabetes nephropathy animals,but it needs to be further confirmed by a large sample clinical trial with higher quality and strict specifications.关键词
大黄素/糖尿病肾病/动物实验/系统评价Key words
Emodin/Diabetic nephropathy/Animal experiment/Systematic review分类
医药卫生引用本文复制引用
何望,黄国顺,张凯钰,周恩超..基于动物实验系统评价大黄素治疗糖尿病肾病的可行性[J].海南医学院学报,2024,30(6):451-462,12.基金项目
This study was supported by National Natural Science Foundation of China(81873270) （81873270）
Nanjing Municipal Bureau of Science and Technology Medical and Health International Joint Research and Development Project(202002051) （202002051）
Nanjing University of Traditional Chinese Medicine Advantage Discipline Phase Ⅲ Project(ZYX03KF076) 国家自然科学基金资助项目(81873270) （ZYX03KF076）
南京市科技局医疗卫生国际联合研发项目(202002051) （202002051）
南京中医药大学中医学优势学科三期项目(ZYX03KF076) （ZYX03KF076）
