海南医学院学报2024，Vol.30Issue(6)：469-474,6.DOI:10.13210/j.cnki.jhmu.20230717.002
细胞焦亡在糖尿病创面愈合中的研究进展
Research progress of pyroptosis in diabetic wound healing
摘要
Abstract
Diabetic wound is one of the common complications of diabetes.It has the characteristics of protracted and re-fractory to care.In severe cases,patients will face the risk of amputation.How to effectively manage and treat diabetic chronic re-fractory wounds has become an urgent problem to be solved.Pyroptosis is an inflammatory type of programmed cell death,usually triggered by inflammasomes.Pyroptosis-driven cell death is mainly mediated by the traditional signaling pathway induced by cas-pase-1 and the non-classical signaling pathway induced by caspase-4/5/11.Many evidences have shown that pyroptosis plays an ex-tremely important role in the healing process of diabetic wounds.This article reviews the mechanisms of pyroptosis-related signal-ing pathways and their effects on diabetic wounds in recent years,in order to guide the clinical treatment and mechanism research of diabetic refractory wounds.关键词
细胞焦亡/糖尿病/创面愈合/综述Key words
Pyroptosis/Diabetes/Wound Healing/Review分类
医药卫生引用本文复制引用
竺仕林,葛星月,杨雅量,李文武,姚明哲,唐乾利..细胞焦亡在糖尿病创面愈合中的研究进展[J].海南医学院学报,2024,30(6):469-474,6.基金项目
This study was supported by 2017 National Natural Science Foundation General Project(81774327) （81774327）
Special Funding for the Training of Candidates for the"139"Plan for High-level and Secondary Backbone Talents in Guangxi Medicine[Guiwei Kejiao Fa(2018)No.22] （2018）
Guangxi Graduate Education Innovation Program Project[Gui Degree(2022)No.13](YCSW2023496) 2017年国家自然科学基金面上项目(81774327) （2022）
广西医学高层次骨干人才"139"计划培养人选培养专项资助[桂卫科教发(2018)22号] （2018）
广西研究生教育创新计划项目[桂学位(2022)13号](YCSW2023496) （2022）
