郑州大学学报（医学版）2024，Vol.59Issue(2)：260-265,6.DOI:10.13705/j.issn.1671-6825.2023.07.038
舒洛地特联合缬沙坦对2型糖尿病肾病患者肾保护作用的随机对照临床试验
Renal protective effects of sulodexide combined with valsartan in patients with type 2 diabetic nephropathy:a randomized controlled clinical trial
摘要
Abstract
Aim:To explore the renal protective effects of sulodexide combined with valsartan on type 2 diabetic ne-phropathy and its influencing factors.Methods:A total of 98 patients with type 2 diabetic nephropathy were selected and al-located into conventional group(n =49)and study group(n =49).The conventional group was treated with valsartan(80 mg per time,once per day),while the study group was treated with sulodexide on the basis of the conventional group(250 LSU per time,twice per day)for 3 months.The curative effects,incidence of adverse reactions,renal function indexes[urea nitro-gen(BUN),serum creatinine(Scr)and 24-hour urinary protein],glucose and lipid metabolism indexes[fasting blood glu-cose(FPG),triglyceride(TG),glycosylated hemoglobin(HbA1c)and total cholesterol(TC)]before and after treatment were compared between the 2 groups.The influencing factors on the overall curative effects were analyzed.Results:The to-tal effective rate of treatment in the study group was higher than that of the conventional group(P =0.037).After treat-ment,the levels of BUN,Scr,24-hour urinary protein,FPG,HbA1c,TG,and TC in the study group were lower than those in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P =0.674).The course of disease(OR =4.186,95%CI was 2.491-7.033),glomerulosclerosis(OR =5.865,95%CI was4.216-8.159),stages of diabetic nephropathy(OR = 5.742,95%CI was 3.512-9.387),hypertension(OR =4.134,95%CI was 2.455-6.960)and treatment plan(OR =5.597,95%CI was 3.958-7.915)were the influ-encing factors of overall curative effects(P<0.05).Conclusion:Sulodexide combined with valsartan has significant thera-peutic effects on type 2 diabetic nephropathy,which could improve glucose and lipid metabolism and protect renal function.The course of disease,stage of diabetic nephropathy,hypertension,glomerulosclerosis and treament plan are factors affecting the overall curative effects.关键词
舒洛地特/糖尿病肾病/缬沙坦/肾功能/影响因素Key words
sulodexide/diabetic nephropathy/valsartan/renal function/influencing factor分类
医药卫生引用本文复制引用
布海霞,郭利芹,徐可,王焕..舒洛地特联合缬沙坦对2型糖尿病肾病患者肾保护作用的随机对照临床试验[J].郑州大学学报（医学版）,2024,59(2):260-265,6.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20220988) （LHGJ20220988）
河南省医学科技攻关计划项目(LHGJ20200948) （LHGJ20200948）
