郑州大学学报（医学版）2024，Vol.59Issue(2)：280-283,4.DOI:10.13705/j.issn.1671-6825.2023.10.080
河南省农村人群糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系
Relationship between genetic polymorphisms of glucocorticoid receptor rs9324921 and rs9324924 and stroke among rural population in Henan Province
摘要
Abstract
Aim:To assess the relationship of glucocorticoid receptors(GR)SNP sites rs9324921 and rs9324924 with stroke among rural population in Henan Province.Methods:A total of 255 stroke patients from the survey of"Henan Rural Cohort"from 2015 to 2017 were selected.According to gender and age difference within 3 years,the control population(n = 765)participated at the same time was matched with the ratio of 3∶1.rs9324921 and rs9324924 were genotyped using SNPscan after DNA was extracted from whole blood.Logistic regression model was used to assess the correlations between GR rs9324921 and rs9324924 and stroke.Results:After adjusting for confounding factors,allele A or genotype AA at the rs9324921 locus,and allele T or genotype TT at the rs9324924 locus had a significantly higher risk of stroke,with OR(95%CI)of 1.374(1.071-1.762),2.240(1.173-4.280),1.414(1.143-1.748),2.035(1.330-3.111),respectively.Conclusion:Allele A at the rs9324921 locus and allele T at the rs9324924 locus of the GR gene are associated with higher risk of stroke among rural population in Henan Province.关键词
糖皮质激素受体/脑卒中/基因多态性/河南省Key words
glucocorticoid receptor/stroke/gene polymorphism/Henan Province分类
医药卫生引用本文复制引用
徐克,史佳雨,马翠翠,赵梦真,耿巾甜,毛振兴,付余..河南省农村人群糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系[J].郑州大学学报（医学版）,2024,59(2):280-283,4.基金项目
国家自然科学基金项目(42177415) （42177415）
中国博士后科学基金项目(2020T130604) （2020T130604）
河南省高校科技创新人才支持计划项目(22HASTIT044) （22HASTIT044）
