郑州大学学报（医学版）2024，Vol.59Issue(2)：178-181,4.DOI:10.13705/j.issn.1671-6825.2023.03.034
七氟烷后处理对脑缺血再灌注成年大鼠远期神经功能的影响
Postconditioning with sevoflurane improves long-term neurological out-comes after focal cerebral ischemia-reperfusion injury in rats
摘要
Abstract
Aim:To investigate the long-term effect of postconditioning with sevoflurane in rats with cerebral ischemia-reperfusion injury.Methods:Male rats were randomly allocated into 3 groups,rats in model group and sevoflurane group were subjected to suffer transient middle cerebral artery occlusion(MCAO)for 90 min and rats in the sham group were sub-jected to the same surgery procedures except for occlusion of the middle cerebral artery for 90 min.Afterward,they were ex-posed to 1.0 MAC sevoflurane,O2,or 1.0 MAC sevoflurane for 30 min at the beginning of reperfusion.The neurological def-icit scores were evaluated from the 1st day to the 29th day after reperfusion every 48 hours(25 in each group).Infarct vol-ume was evaluated on the 29th day after reperfusion by TTC staining(6 rats in each group).Brain water content was evalua-ted at 24 hours after reperfusion(3 rats in each group).Results:Infarct volume of sevoflurane group[(38.9±5.9)]%was less than that[(46.8±5.5)%]of model group on the29th day(P<0.05).Neurological deficit scores of sevoflurane group on the 1st day and 13th day were(1.25±0.44)and(0.63±0.59),both lower than those[(2.00±0.72)and(1.25±0.44)]of model group(P<0.05).Brain water content of sevoflurane group[(80.5±1.0)%]was lower than that[(84.0±0.8)%]of model group(P<0.05).Conclusion:Postconditioning with sevoflurane could improve early neurological function after cerebral ischemia-reperfusion in adult rats.关键词
脑缺血再灌注损伤/七氟烷/远期效果/大鼠Key words
cerebral ischemia-reperfusion injury/sevoflurane/long-term efficacy/rat分类
医药卫生引用本文复制引用
王俊宽,许柯炎,秦瑞鸿,陈高..七氟烷后处理对脑缺血再灌注成年大鼠远期神经功能的影响[J].郑州大学学报（医学版）,2024,59(2):178-181,4.基金项目
河南省自然科学基金项目(162300410307) （162300410307）
河南省卫生健康科技英才海外研修工程项目(HWYX2019052) （HWYX2019052）
