郑州大学学报（医学版）2024，Vol.59Issue(2)：212-215,4.DOI:10.13705/j.issn.1671-6825.2023.11.076
早卵泡期长效长方案促排卵过程中内源性黄体生成素升高后拮抗剂的应用对临床结局的影响
Clinical outcomes of the antagonists use for endogenous luteinizing hor-mone elevation during ovulation induction in early follicular phase long protocol
摘要
Abstract
Aim:To investigate the effects of the antagonists on clinical outcomes of fresh cycle transplantation after en-dogenous luteinizing hormone(LH)elevation during ovulation induction in early follicular phase long protocol.Methods:A retrospective analysis was performed on 240 cycles undergoing in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)embryo transfer treatment with early follicular phase long protocol and endogenous LH elevation during ovulation in-duction in the Reproductive Medical Center of Henan Provincial People's Hospital from September 2016 to December 2022.They were allocated into 2 groups according whether antagonists were added,and 1∶1 matching was performed by propensity score matching:group A(added antagonists)97 cycles,group B(no antagonists added)97 cycles.The differences between the 2 groups in the clinical indicators during ovulation induction and clinical outcomes of fresh cycle transplantation were compared.Results:The duration of Gn used,LH on Gn start day,LH on the day before hCG day,and number.of MⅡ oo-cytes in group A were significantly higher than those in group B,while LH on hCG day in group A was significantly lower than that in group B(P<0.05).There were no statistical differences in the average number of transplanted embryos,pro-portion of cleavage embryo transfer,clinical pregnancy rate,ectopic pregnancy rate or live birth rate between the 2 groups(P>0.05).Conclusion:Addition of the antagonists when endogenous LH is elevated during ovulation induction in the ear-ly follicular phase long protocol can effectively inhibit the level of LH,and improve the clinical outcomes of fresh cycles.关键词
早卵泡期长效长方案/黄体生成素/拮抗剂/新鲜周期/倾向性评分Key words
early follicular phase long protocol/luteinizing hormone/antagonist/fresh cycle/propensity score分类
医药卫生引用本文复制引用
张宜瑄,王淑娜,路锦,张翠莲,张少娣..早卵泡期长效长方案促排卵过程中内源性黄体生成素升高后拮抗剂的应用对临床结局的影响[J].郑州大学学报（医学版）,2024,59(2):212-215,4.基金项目
国家自然科学基金项目(U2004130) （U2004130）
河南省医学科技攻关项目(LHGJ20220049) （LHGJ20220049）
